Abstract Patients with estrogen receptor–positive breast cancer receive adjuvant endocrine therapies (ET) that delay relapse by targeting clinically undetectable micrometastatic deposits. Yet, up to 50%
Abstract The transcription factor MYC is overexpressed in most cancers, where it drives multiple hallmarks of cancer progression. MYC is known to promote oncogenic transcription
Abstract In metastasis, cancer cells travel around the circulation to colonize distant sites. Due to the rarity of these events, the immediate fates of metastasizing
Abstract Transient reprogramming by the expression of OCT4, SOX2, KLF4 and MYC (OSKM) is a therapeutic strategy for tissue regeneration and rejuvenation, but little is
Highlights Summary All living things experience an increase in entropy, manifested as a loss of genetic and epigenetic information. In yeast, epigenetic information is lost
Abstract After viral entry and reverse transcription, HIV-1 proviruses that fail to integrate are epigenetically silenced, but the underlying mechanism has remained unclear. Using a
By studying how different pluripotent stem cell lines build muscle, researchers have for the first time discovered how epigenetic mechanisms can be triggered to accelerate
Nicotine can wield its effects on offspring in more ways than from exposures in utero or secondhand smoke: the sperm of mice that ingested nicotine
An international team of researchers has found that the immune system reacts to typically high-calorie, Western-style diets in much the same way that it does
Cigarette smoke contributes to epigenetic and genetic changes in lung cancer. But whether and how these alterations interact in lung cancer initiation has remained unclear.
Some big ideas seem to appear out of nowhere, but in 2008 Chuan He deliberately went looking for one. The US National Institutes of Health
Epigenetic abnormalities are part of the pathogenetic alterations involved in the development of rheumatic disorders. In this context, the main musculoskeletal cell lineages, which are
A commonly prescribed antidepressant exerts epigenetic effects that may provide a useful biomarker of whether the drug works in patients. A team led by researchers
Genome-wide epigenetic and transcription analyses of monocytes and macrophages have uncovered two crucial pathways driving macrophage training a recently discovered form of innate immune memory
In the process of converting a somatic cell to a stem cell, researchers have questioned whether the resulting cells retain characteristics of their prior, non-stem-cell
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