Scientists Doubt Results of CRISPR’d Embryos
In a seminal study published earlier this month in Nature, researchers used CRISPR gene-editing technology to repair a heart-disease inducing genetic mutation in human embryos.
In a seminal study published earlier this month in Nature, researchers used CRISPR gene-editing technology to repair a heart-disease inducing genetic mutation in human embryos.
Highlights •Phage-encoded anti-CRISPRs (Acrs) inhibit CRISPR-Cas9 through unique mechanisms •AcrIIC1 controls genome editing by diverse Cas9 orthologs •AcrIIC1 binding disables Cas9’s nucleases without impacting DNA
Researchers have been studying the CRISPR-Cas9 gene-editing system as a potential therapeutic tool to modify or delete pathogenic sequences within the human genome. Now, using
It was the injection heard around the world. On October 28th, a team of scientists at Sichuan University in Chengdu, China, delivered the first cells
The blood disorder, β-thalassaemia, is considered an attractive target for gene correction. Site-specific triplex formation has been shown to induce DNA repair and thereby catalyse
In gene editing, the kindest cut may be no cut at all. This possibility was explored by researchers working with peptide nucleic acids (PNAs), synthetic
The revolutionary gene editing technology CRISPR-Cas is on the verge of widespread application in agriculture, promising easy access to dramatic crop improvements. Companies now licensing
Taking advantage of a deaminase enzyme that introduces a single nucleotide change to DNA, researchers have created a modified CRISPR/Cas9tool that avoids the generation of
Oncologist You Lu of Sichuan University’s West China Hospital in Chengdu and colleagues will soon begin trialing a new CRISPR-based immunotherapy in 10 patients with
A team of researchers at the Gladstone Institutes in San Francisco, California, has used a version of CRISPR gene editing known as CRISPR interference (CRISPRi) to
Imaging Life-science imaging broke barriers this year, as scientists built upon microscopy approaches to peer ever deeper into living tissues. In October, Purdue University’s Ji-Xin
A team of researchers has taken a step toward modifying pigs to become viable alternatives to human organ donors, George Church from Harvard University announced
Scientists at the Harvard Stem Cell Institute at Massachusetts General and Boston Children’s hospitals say that a novel gene editing method has been used to
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