Advancing Techniques Reveal the Brain’s Impressive Diversity
For years, neurons in the brain were assumed to all carry the same genome, with differences in cell type stemming from epigenetic, transcriptional, and posttranscriptional
For years, neurons in the brain were assumed to all carry the same genome, with differences in cell type stemming from epigenetic, transcriptional, and posttranscriptional
Two studies published today (October 23) document a slew of common genetic variants that correlate with an increased or decreased risk of developing breast cancer.
Base editing is a relatively recent genome-editing technique that swaps one DNA base pair for another, offering researchers the potential to correct harmful, single-nucleotide mutations
Fusing an RNA-editing enzyme to an RNA-targeting Cas protein has enabled researchers to edit specific nucleotides within RNA molecules in human cells. The approach, called
Genomic data from more than 400 individuals has been combined with information on genetic activity within multiple tissues from these donors to produce a detailed
Today (October 2), Michael Rosbash, Jeffrey Hall, and Michael Young were awarded the 2017 Nobel Prize in Physiology or Medicine for explaining how organisms synch
Today (October 2), Michael Rosbash, Jeffrey Hall, and Michael Young were awarded the 2017 Nobel Prize in Physiology or Medicine for explaining how organisms synch
One mutation in the Zika virus is responsible for catastrophic consequences in its hosts. A sequence change resulting in one amino acid substitution can convert
A team of Chinese researchers who were the first to report having applied CRISPR to human embryos have done it again—this time upgrading their technique
Scientists have used the gene-editing CRISPR-Cas9 system to suppress the gene encoding the protein OCT4 in experiments with human embryos. According to the results, published
One day in 2006, while a postdoc in the Rockefeller University laboratory of Nathaniel Heintz, I had an unexpected eye-opener. Heintz showed me some electron
Armed with a modified version of CRISPR-Cas9, scientists have removed nucleotide repeats from RNA in vitro that are known to cause diseases, namely, Huntington’s, ALS,
Last week, word got out that a team of scientists had edited viable human embryos for the first time in the United States. Details of
In what appear to be the largest RNAi screening efforts in cancer to date, two groups of scientists have tamped down the expression of thousands
For the first time, researchers report the use of the mutagenic chemical N-ethyl-N-nitrosourea (ENU) to conduct a genetic screen in pigs. The data reveal mutations
EDITOR’S CHOICE IN GENETICS & GENOMICS The paper M.D.W. Piper bracelets et al., “Matching dietary amino acid balance to the in silico–translated exome optimizes growth
Around half of all organ transplants in humans are rejected by the cartier jewelry replica recipient’s immune system within 10 to 12 years. Scientists studying
Researchers have been studying the CRISPR-Cas9 gene-editing system as a potential therapeutic tool to modify or delete pathogenic sequences within the human genome. Now, using
For people with no perceivable health issues but who are curious about some potential future ailments, there are now a handful of companies offering whole-genome
Genetically, tumors are a mess. Individual tumor cells have a unique spectrum of mutations, and this heterogeneity is known to drive tumor evolution and resistance
Neurodegenerative diseases are often associated with aging. To learn what happens within the aging brain and potentially gain information relevant to human health, researchers examined
In a unique twist on human genomics studies that seek to identify genetic variants linked to human disease, researchers have combined whole-exome sequencing of 50,726
Viromes from a variety of environments harbor antibiotic resistance genes, according to a study published last month (November 24) in Environmental Pollution. The results suggest
Over the next decade, researchers will compile a comprehensive and freely available map of the cells of the human body, complete with descriptions about their
The first reports of the disease that would later be known as HIV/AIDS came in 1981, when AIDS-related conditions were already on the rise, particularly
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