Some people in hospital die not from the illness or accident that got them admitted but from germs they catch once there. In the United
Abstract Inflammation is a complex physiological process triggered in response to harmful stimuli1. It involves cells of the immune system capable of clearing sources of
Abstract After viral entry and reverse transcription, HIV-1 proviruses that fail to integrate are epigenetically silenced, but the underlying mechanism has remained unclear. Using a
Abstract Tissue-resident memory T cells (TRM cells) provide protective immunity, but the contributions of specific tissue environments to TRM cell differentiation and homeostasis are not well understood.
Highlights •History of SARS-CoV-2 infection affects longitudinal responses to BNT162b2 vaccine •Lower humoral but enhanced cellular responses early after vaccine in naïve subjects •Comparable humoral
arly in the pandemic, some believed that the arrival of summer would make COVID-19 cases drop, much like the flu. In March 2020, Brazil’s president
Abstract This study examined whether CD8+ T-cell responses from COVID-19 convalescent individuals (n=30) potentially maintain recognition of the major SARS-CoV-2 variants (n=45 mutations assessed). Only
Concerns about coronavirus variants that might be partially resistant to antibody defences have spurred renewed interest in other immune responses that protect against viruses. In
Good news from Israel. Researchers are seeing signs that COVID-19 vaccines are helping to curb infections and hospitalizations among older people, almost 6 weeks after
Abstract MAPK-targeting in cancer often fails due to MAPK-reactivation. MEK inhibitor (MEKi) monotherapy provides limited clinical benefits but may serve as a foundation for combination.
Doctors have reported the first confirmed cases of individuals who have tested positive for SARS-CoV-2 infection a second time. The first report was of a patient
Scientists at Scripps Research have discovered a molecule that can activate a natural immune-boosting protein called STING. The findings mark a key advance in the
Highlights 1.Acute phase SARS-CoV-2-specific T cells display an activated cytotoxic phenotype 2.Broad and polyfunctional SARS-CoV-2-specific T cell responses in convalescent phase 3.Detection of SARS-CoV-2-specific T
Highlights •Measuring immunity to SARS-CoV-2 is key for understanding COVID19 and vaccine development •Epitope pools detect CD4+ and CD8+ T cells in 100 and 70% of convalescent
Immune warriors known as T cells help us fight some viruses, but their importance for battling SARS-CoV-2, the virus that causes COVID-19, has been unclear.
W hether people develop immunity to SARS-CoV-2 after being infected once is a pressing question for policymakers, public health professionals, and everyone affected by the
Immune cells altered by CRISPR are safe to use in cancer patients, according to results of a clinical trial reported today (February 6) in Science.
Children who survive measles are protected against future measles infections, but have such diminished immunity that they may be left vulnerable to other pathogens, according
According to the World Health Organization, cases of pertussis, also known as whooping cough, reported in the US increased from fewer than 8,000 in 2000
Platelets do more than promote clotting. They weaken one of the body’s immune defenses against cancer. Unfortunately, platelets tend to work against the immuno-oncology treatments
Type I interferons have been shown to play a major role in anti-cancer immunity. In this issue of Cancer Cell, Katlinski et al. describe tumor-induced degradation
Microbes use a number of CRISPR-Cas systems for immunity, but it’s the class 2 system, typically utilizing the nuclease Cas9, that has been adapted for
Cyclin suppresses antitumor immunity Despite the dramatic success of cancer immunotherapy, many types of cancer do not respond. Understanding why could help us to find
As we age, our immune systems change; in many ways not for the better. For instance, the elderly account for 90% of influenza deaths annually.
Pregnant mice expose their unborn pups to maternal gut microbes, which can affect the development of the innate immune system after birth, according to a
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