Abstract This study examines inhibiting galectin 1 (Gal1) as a treatment option for hepatocellular carcinoma (HCC). Gal1 has immunosuppressive and cancer-promoting roles. Our data showed that Gal1 was highly expressed in
Abstract Malaria is caused by Plasmodium species transmitted by Anopheles mosquitoes. Following a mosquito bite, Plasmodium sporozoites migrate from skin to liver, where extensive replication occurs, emerging later as merozoites that
Highlights Summary Ideal therapies for regenerative medicine or healthy aging require healthy organ growth and rejuvenation, but no organ-level approach is currently available. Using Mycobacterium leprae (ML)
Zoning in on liver growth For organ homeostasis or regrowth after injury or disease, one or more stem cell populations is needed to rebuild lost
Organoids regenerate human bile ducts Bile ducts carry bile from the liver and gall bladder to the small intestine, where it aids digestion. Cholangiocytes are
Researchers have identified one possible cause of nonalcoholic fatty liver disease, a common disorder in which fat builds up in the liver with potentially life-threatening
RNA sequencing may help doctors diagnose hepatocellular carcinoma earlier, according to preliminary data presented Sunday (March 31) at the American Association for Cancer Research annual
Anticipating something tasty can lead to a watering mouth and grumbling stomach, but these familiar responses aren’t the only ways the body prepares for nourishment.
Two studies published yesterday (October 9) in Nature Medicine report success using modified CRISPR-Cas9 gene editing to prevent or cure two inherited diseases in mice.
Setting liver regeneration free The liver is an excellent model of organ regeneration; however, regeneration may fail in a normal liver after acute severe injury
One strategy to treat type 1 diabetes, where the immune system destroys insulin-producing β cells, is to convert other cells into β-like cells that then
Researchers have edited the human genome before, but always in cells outside the body. Now, biotech company Sangamo Therapeutics is recruiting participants for clinical trials
In a first, a man has received a therapy aimed at editing the genes inside his body. The Associated Press reports that 44-year-old Brian Madeux,
Engineering human livers is a lofty goal. Human liver cells, hepatocytes, are particularly difficult to grow in the laboratory as they lose liver functions quickly
Researchers have edited the human genome before, but always in cells outside the body. Now, biotech company Sangamo Therapeutics is recruiting participants for clinical trials
Proceedings of the National Academy of Sciences (July 2011), doi:10.1073/pnas.1101791108 . Chen, A. et al. “Humanized mice with ectopic artificial liver tissues”. Mice with miniature
Proceedings of the National Academy of Sciences (July 2011), doi:10.1073/pnas.1101791108 . Chen, A. et al. “Humanized mice with ectopic artificial liver tissues”. Mice with miniature
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