Significance Enterococci are among the most widely distributed microbes in animal gut consortia. Over 60 species have been identified, including Enterococcus faecalis and Enterococcus faecium commonly found in the
Abstract Immune checkpoint blockade (ICB) targeting programmed cell death protein 1 (PD-1) and cytotoxic T lymphocyte protein 4 (CTLA-4) can induce remarkable, yet unpredictable, responses
Abstract Natto, known for its high vitamin K content, has been demonstrated to suppress atherosclerosis in large-scale clinical trials through a yet-unknown mechanism. In this
Abstract Insulin resistance is the primary pathophysiology underlying metabolic syndrome and type 2 diabetes1,2. Previous metagenomic studies have described the characteristics of gut microbiota and
Abstract A growing body of evidence suggests that dysbiosis of the human gut microbiota is associated with neurodegenerative diseases like Alzheimer’s disease (AD) via neuroinflammatory
Abstract Parkinson’s disease (PD) may start in the gut and spread to the brain. To investigate the role of gut microbiome, we conducted a large-scale
Abstract Variation in the blood metabolome is intimately related to human health. However, few details are known about the interplay between genetics and the microbiome
Highlights •Gut microbiome was associated with multiple sclerosis (MS) risk and disease stage •Distinct microbe-microbe interactions were found in MS patients •Disease-modifying therapy modulates gut
Summary The human microbiome constitutes a complex multikingdom community that symbiotically interacts with the host across multiple body sites. Host-microbiome interactions impact multiple physiological processes
Abstract Bacteria in the gut can modulate the availability and efficacy of therapeutic drugs. However, the systematic mapping of the interactions between drugs and bacteria
Highlights •Diet intervention with systems profiling reveals links in diet-microbiome-immune axis •High-fiber diet changes microbiome function and elicits personalized immune responses •Fermented-food diet increases microbiome
Abstract We propose microbiome disease “architectures”: linking >1 million microbial features (species, pathways, and genes) to 7 host phenotypes from 13 cohorts using a pipeline
Researchers with the Snyder Institute for Chronic Diseases at the Cumming School of Medicine (CSM) have discovered which gut bacteria help our immune system battle cancerous tumours and how
Highlights •Psychological stress triggers vaso-occlusive episodes (VOEs) in sickle cell disease •Stress-induced VOEs depend on the microbiota •The stress response is enabled by the hypothalamic-pituitary-adrenal
The world is filled with microorganisms, which have a profound impact on many facets of life. Do these microbial communities influence cancer1? Many studies of
Highlights The literature describing the differences in microbiota features between individuals with cancer and matched controls has undergone dramatic recent expansion. Mechanistic models for how
Human diseases are increasingly linked with an altered or “dysbiotic” gut microbiota, but whether such changes are causal, consequential, or bystanders to disease is, for
Mounting evidence in animal models, as well as correlative studies in humans, indicate that the microbes present in the gut can shape immune responses. In
Gut bacteria harbor enzymes and pump out other molecules that can influence how medications are activated or broken down. One example is the Parkinson’s drug
When Sara Campbell first typed “exercise and microbiome” into PubMed in 2010 and hit enter, “the search literally said zero,” she tells The Scientist. Campbell
Genetics hold far more sway over the mouse microbiome than transient environmental exposures, researchers reported July 26 in Applied and Environmental Microbiology. The results appear
In a mouse model of amyotrophic lateral sclerosis, animals that had ample levels the bacterium Akkermansia muciniphila in their gut microbiomes fared better than those
Even once they have enough to eat, kids that have suffered from malnutrition do not grow and develop as well as kids that have always
A few years ago, microbiologist Catherine Lozupone and colleagues at the University of Colorado were studying metabolism-related health problems in men and women infected with
University of Chicago immunologist Cathryn Nagler began to suspect that the body’s resident bacteria play a role in food allergies almost two decades ago. A
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