Highlights Summary The dominant risk factors for late-onset Alzheimer’s disease (AD) are advanced age and the APOE4 genetic variant. To examine how these factors alter neuroimmune function,
Highlights Summary Spinal cord injury (SCI) causes lifelong debilitating conditions. Previous works demonstrated the essential role of the immune system in recovery after SCI. Here,
Abstract A growing body of evidence suggests that dysbiosis of the human gut microbiota is associated with neurodegenerative diseases like Alzheimer’s disease (AD) via neuroinflammatory
Highlights Summary HIV-1 encounters the hierarchically organized host chromatin to stably integrate and persist in anatomically distinct latent reservoirs. The contribution of genome organization in
Abstract Myelin is required for the function of neuronal axons in the central nervous system, but the mechanisms that support myelin health are unclear. Although
Abstract Microglia are emerging as key drivers of neurological diseases. However, we lack a systematic understanding of the underlying mechanisms. Here, we present a screening
Alzheimer’s disease (AD) is characterized by accumulation of misfolded proteins. Genetic studies implicate microglia, brain-resident phagocytic immune cells, in AD pathogenesis. As positive effectors, microglia
Highlights •Repeated ketamine anesthesia induces perineuronal net loss •PNN loss reinstates juvenile-like ocular dominance plasticity •Microglia interact with parvalbumin neurons and remodel PNN •60-Hz light
Abstract One of the greatest influenza pandemic threats at this time is posed by the highly pathogenic H5N1 avian influenza viruses. To date, 61% of
Sequencing the nuclear RNA of more than 100,000 individual postmortem brain cells from people with and without autism spectrum disorder indicates the types of genes
Microglia are phagocytic cells that remove cellular debris and aggregated proteins from the brain and prune unwanted and degenerating synapses (1). When the brain is
Microglia are phagocytic cells that remove cellular debris and aggregated proteins from the brain and prune unwanted and degenerating synapses (1). When the brain is
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