Abstract Once considered as a “metabolic waste,” lactate is now recognized as a major fuel for tricarboxylic acid (TCA) cycle. Our metabolic flux analysis reveals
Abstract Mitochondrial DNA (mtDNA) encodes essential subunits of the oxidative phosphorylation system, but is also a major damage-associated molecular pattern (DAMP) that engages innate immune
Highlights Summary Phospholipids containing a single polyunsaturated fatty acyl tail (PL-PUFA1s) are considered the driving force behind ferroptosis, whereas phospholipids with diacyl-PUFA tails (PL-PUFA2s) have
Abstract Mitochondria are critical to the governance of metabolism and bioenergetics in cancer cells1. The mitochondria form highly organized networks, in which their outer and
Abstract Understanding the mechanisms governing selective turnover of mutation-bearing mtDNA is fundamental to design therapeutic strategies against mtDNA diseases. Here, we show that specific mtDNA
Highlights •Altered mitochondrial homeostasis reprograms cell death modalities •Mitochondrial ROS directs GSDMD to mitochondria following inflammasome activation •Mito-GSDMD shifts cell death from pyroptosis to necroptosis
Abstract Acute myeloid leukemia (AML) is a heterogeneous group of aggressive hematological malignancies commonly associated with treatment resistance, high risk of relapse, and mitochondrial dysregulation.
Highlights • Dead-guide RNA-based CRISPR activation screen identifies targets for CAR-T engineering• PRODH2 gain of function reprograms proline metabolism in CD8+ T cells• PRODH2 reshapes transcriptome, metabolome, and immune
Abstract Heteroplasmic mitochondrial DNA (mtDNA) mutations are a common cause of inherited disease, but a few recurrent mutations account for the vast majority of new
Abstract Glutathione (GSH) is a small-molecule thiol that is abundant in all eukaryotes and has key roles in oxidative metabolism1. Mitochondria, as the major site
Highlights • Mitochondria in the mouse brain are long lived and show considerable age mosaicism• Mitochondria contain many LLPs as part of protein complexes• LLPs
Key Points SCD patients have elevated cell-free mitochondrial DNA (cf-mtDNA) that can be sourced to abnormal retention of mitochondria in RBCs The cf-mtDNA is disproportionately
Researchers from the UCLA Jonsson Comprehensive Cancer Center say have developed a simple, high-throughput method for transferring isolated mitochondria and their associated mitochondrial DNA into
In a biological beating of swords into plowshares, researchers have converted a bacterial toxin into a genome editing tool that, for the first time, can
For many years, Thomas Misgeld, a neuroscientist at the Technical University of Munich in Germany, has studied mitochondria, often in the context of neurodegenerative and
From Alaska down to the Baja Peninsula, the rocky tide pools of North America’s West Coast are separated by hundreds of kilometers of sandy beaches.
Typically, humans inherit mitochondria and mitochondrial DNA from their mothers only. But using sequencing data from the mitochondrial genomes of members from three unrelated families,
Researchers in the US and Europe have used two gene-editing approaches to correct mitochondrial mutations in live mice. The results, published yesterday (September 24) in
Mitochondrial dysfunction and subsequent metabolic deregulation is observed in neurodegenerative diseases and aging. Mutations in the presenilin (PSEN) encoding genes (PSEN1 and PSEN2) cause most
Abstract Most of the hematopoietic stem cells (HSCs) within the bone marrow (BM) show quiescent state with a low mitochondrial membrane potential (ΔΨm). In contrast,
In the nematode worm Caenorhabditis elegans, as in humans, offspring inherit mitochondria and mitochondrial DNA only from their mother. Sato et al. identified key molecular
When cells in our body die, it is important that they are cleared from the system so that they do not cause inflammation or further
Abstract We report that the anticancer activity of the widely used diabetic drug metformin is strongly potentiated by syrosingopine. Synthetic lethality elicited by combining the
The vast majority of genes in sexually reproducing eukaryotes can recombine during the production of gametes. This reshuffling generates new genotypes that may provide selective
Mitochondria contain proteins encoded by the nucleus and by their own mitochondrial genome. Sometimes protein synthesis within the mitochondria goes wrong, which can damage both
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