Despite the recent progress made in treating melanoma, an ongoing issue is the development of drug resistance to promising target-specific therapeutic strategies, resulting in treatment
lthough CAR T cells have made their claim to fame in treating leukemia and lymphoma, scientists have now shown they can be directed toward other
Highlights • Changes in the gut microbiota are required for the anti-seizure effects of the KD • Specific KD-associated bacteria mediate and confer the anti-seizure
One strategy to treat type 1 diabetes, where the immune system destroys insulin-producing β cells, is to convert other cells into β-like cells that then
Using a process called in situ vaccination, in which the host’s immune system is recruited to attack cancer cells, researchers were able to clear injected
The thymus, an organ in the lymphatic system, plays a critical role in immune function, producing the T cells essential to the immune response. While
Engineering human livers is a lofty goal. Human liver cells, hepatocytes, are particularly difficult to grow in the laboratory as they lose liver functions quickly
As many as 8 percent of pregnant women develop a condition known as preeclampsia, a spike in blood pressure characterized by the reduced formation of
Researchers have been studying the CRISPR-Cas9 gene-editing system as a potential therapeutic tool to modify or delete pathogenic sequences within the human genome. Now, using
It’s no secret that fewer than 10 percent of investigational drugs achieve regulatory approval and reach the marketplace. But the chances of success for drugs
Mice with certain mutations in the touch receptors in their skin are more easily startled by small puffs of air than their wild-type counterparts, according
Myc, a transcriptional regulator that is overexpressed in several human cancers, appears to have a direct role in preventing immune cells from efficiently attacking tumor
n 1993, National Institutes of Health (NIH) researchers gave Eli Lilly’s promising experimental hepatitis B drug fialuridine to 15 patients as part of a small
Researchers investigating host responses to Ebola have long faced a significant disadvantage: the virus kills conventional lab mice, but does not produce the hemorrhagic fever
The history of a grandmother’s stressful environment during pregnancy can be passed on to her grandchildren, according to a study published today (August 7) in BMC
The effects of malnutrition in the late stages of a female mouse’s pregnancy can produce epigenetic changes in the sperm of her male offspring. While
Genes & Development, 2011 DOI: 10.1101/gad.17269211. Johannes Zuber, Amy R. Rappaport, Weijun Luo, Eric Wang, Chong Chen, Angelina V. Vaseva, Junwei Shi, Susann Weissmueller, Meredith
Genes & Development, 2011 DOI: 10.1101/gad.17269211. Johannes Zuber, Amy R. Rappaport, Weijun Luo, Eric Wang, Chong Chen, Angelina V. Vaseva, Junwei Shi, Susann Weissmueller, Meredith
Proceedings of the National Academy of Sciences (July 2011), doi:10.1073/pnas.1101791108 . Chen, A. et al. “Humanized mice with ectopic artificial liver tissues”. Mice with miniature
Proceedings of the National Academy of Sciences (July 2011), doi:10.1073/pnas.1101791108 . Chen, A. et al. “Humanized mice with ectopic artificial liver tissues”. Mice with miniature
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