Adult human hippocampi are home to thousands of immature neurons, researchers report today (April 5) in Cell Stem Cell. The result runs counter to a
People with Alzheimer’s have a higher production rate of tau proteins than healthy individuals, according to a study published today (March 21) in Neuron. While
Psychiatric disorders display common patterns of gene expression, according to a study published today (February 8, 2018) in Science. Researchers have analyzed transcripts within the
Cellular factories perform their functions by localizing and trafficking proteins into compartments where they can serve specific purposes. Because of this, a protein’s subcellular coordinates
Researchers in Japan and Australia have developed the first blood test to detect amyloid-β protein buildup in the brain, one of the earliest hallmarks of
People who experience blast-related trauma to the brain, a condition that has become more and more common among combat veterans, can later experience depression and
Studying scorpions comes with its share of danger, as biologist Bryan Fry of the University of Queensland knows all too well. On a 2009 trip
Centuries ago, humans believed that seizures were tied to the lunar cycle. Although scientific evidence for this association is scarce, physicians have long suspected that
Most mammalian cells have a primary cilium, an antenna-like, immobile surface projection that senses the surrounding environment. Researchers report in Nature Genetics today (January 8)
EDITOR’S CHOICE IN NEUROSCIENCE The paper G.E. Doucet et al., “The role of intrinsic brain functional connectivity in vulnerability and resilience to bipolar disorder,” Am
The blood–brain barrier (BBB) keeps neurotoxic plasma-derived components, cells, and pathogens out of the brain. An early BBB breakdown and/or dysfunction have been shown in
On a fall day in 2015 at Sunnybrook hospital in Toronto, a dozen people huddled in a small room peering at a computer screen. They
A small clinical trial testing the safety of administering young people’s blood plasma to treat Alzheimer’s disease has found that the approach may slightly improve
For years, neurons in the brain were assumed to all carry the same genome, with differences in cell type stemming from epigenetic, transcriptional, and posttranscriptional
Neurodegenerative diseases are tough nuts to crack, not just because of the inherent difficulties of sorting through what has gone awry, and why, but also
The eyes of people who read with ease have asymmetrical retinas and also transmit visual information to the brain asymmetrically, according to a report out
In the suprachiasmatic nucleus, the brain’s central pacemaker, CLOCK (circadian locomotor output cycles kaput) is a transcription factor that plays a crucial role in regulating
“Expand your mind, man!” was a popular phrase that arose from the 1960’s counterculture movement. However, it was most likely not referring to the specific
In 2015, the global cost of Alzheimer’s disease was US$818 billion. That’s similar to the gross domestic product of the world’s 18th-largest economy. By 2030,
Interneurons in the brain that use GABA (γ-aminobutyric acid) as a neurotransmitter are essential for functional circuits. During development, these interneurons migrate tangentially from their
One mutation in the Zika virus is responsible for catastrophic consequences in its hosts. A sequence change resulting in one amino acid substitution can convert
A popular chemogenetic technique for controlling cells does not operate in vivo in the way scientists had assumed. Reporting in Science yesterday (August 3), researchers
Neural stem cells normally go with the flow of chemical guides. But with a little electrical stimulation they can be coaxed to go the other
A 21-million-image dataset of the female fruit fly brain is offering an unprecedented view of the cells and their connections that underlie the animal’s behavior.
Summary points Depression is the leading mental health—related cause of the global burden of disease and is the focus of World Health Day 2017. Despite
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