Messenger RNA has been viewed as a potential therapy for several diseases for many years. However, the biggest obstacle to this approach so far has
Ribonuclease P (RNase P) recognizes precursor transfer RNA (pre-tRNA) and processes it to generate mature tRNAs that are used for assembling proteins. Unlike almost all
RNA world models tend to stall at a crucial point: the genetic replication of folded RNA structures. Since these structures include ribozymes, the very elements
Long noncoding RNAs (lncRNAs) are, as the name suggests, long transcripts of RNA that do not code for proteins, but have been found to regulate
Highlights •SRPKIN-1 is the first irreversible inhibitor for SRPK1/2 kinase •SRPKIN-1 is the first kinase inhibitor that targets a tyrosine residue covalently •SRPKIN-1 inhibits phosphorylation
Highlights •SRPKIN-1 is the first irreversible inhibitor for SRPK1/2 kinase •SRPKIN-1 is the first kinase inhibitor that targets a tyrosine residue covalently •SRPKIN-1 inhibits phosphorylation
MicroRNAs (miRNAs) are ∼22 nt RNAs that direct posttranscriptional repression of mRNA targets in diverse eukaryotic lineages. In humans and other mammals, these small RNAs
CRISPR-Cas9 cleaves DNA, enabling genome editing. Surprisingly, three studies have concurrently uncovered an intrinsic RNA cutting activity of Cas9. Cas9 cuts endogenous RNA in some
Thousands of unique non-coding RNA (ncRNA) sequences exist within cells. Work from the past decade has altered our perception of ncRNAs from ‘junk’ transcriptional products
Armed with a modified version of CRISPR-Cas9, scientists have removed nucleotide repeats from RNA in vitro that are known to cause diseases, namely, Huntington’s, ALS,
A very focused function for lncRNAs The human genome generates many thousands of long noncoding RNAs (lncRNAs). A very small number of lncRNAs have been
Biomedical researchers tackling genetic diseases dream of tracing a clean, straight line from discovering a mutation to understanding a disease’s mechanism to developing a curative
A small fraction of proteins have an unusual conformation in which the backbone forms a knot. An example is a bacterial enzyme, TrmD, that transfers
Recent advances in understanding different RNAs and unique features of their biology have revealed a wealth of information. However, approaches to identify small molecules that
The activated spliceosome (Bact) is in a catalytically inactive state and is remodeled into a catalytically active machine by the RNA helicase Prp2, but the
A study of a specific long noncoding RNA in a mouse model of breast cancer shows that knockdown of its expression suppresses metastasis.
While the CRISPR/Cas9 genome editing system has been “burning up the charts”, so to speak, with its extraordinary versatility and potential for treating a host
The RNA-guided endonuclease Cas9 is a versatile genome-editing tool with a broad range of applications from therapeutics to functional annotation of genes. Cas9 creates double-strand
Being able to identify the exact moment when biomolecules are produced would be an invaluable tool for researchers, but in many cases the technology has
New technology called ‘Spinach,’ modeled after Nobel Prize–winning green fluorescent protein. Science 29 July 2011: 642-646 Jeremy S. Paige, Karen Y. Wu, and Samie R.
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