Neural stem cells (NSCs) are ideal recruits for search-and-destroy missions in the brain. They have an innate ability to home in on cancer cells, and
Cancer is notorious for relapsing after treatment. Such relapses are driven by tumor-initiating cells, a type of stem cell that gives rise to tumors. Damelin
Purpose: Investigation of clonal heterogeneity may be key to understanding mechanisms of therapeutic failure in human cancer. However, little is known on the consequences of
Highlights •TLR3 deficiency reduces lung metastasis in the spontaneous cancer metastatic models •Host TLR3 promotes lung pre-metastatic niche formation via neutrophil recruitment •Tumor exosomal RNAs
Abstract Malignant tumors shed DNA into the circulation. The transient half-life of circulating tumor DNA (ctDNA) may afford the opportunity to diagnose, monitor recurrence, and
Cyclin suppresses antitumor immunity Despite the dramatic success of cancer immunotherapy, many types of cancer do not respond. Understanding why could help us to find
Emerging evidence suggests that metastasis the spread of cancer from one organ or tissue to another—is aided by a significant remodeling of the cancer cells’
Vice President Joe Biden, in describing the cancer research initiative President Obama asked him to lead, said “the goal of this initiative—this ‘moonshot’ is to
Highlights •We designed the peptide ReACp53 to halt aggregation of p53 in cells •ReACp53 rescues p53 transcription of target genes and restores apoptosis •In vivo ReACp53
Highlights •Bimodal action: differential consequences of short-versus long-term ERK inhibition •ERK inhibitor sensitivity is associated with MYC degradation in vitro and in vivo •PI3K-AKT-mTOR signaling drives basal
New answers may have just emerged in a long-standing debate in the field of oncology and molecular evolution. The neutral theory of molecular evolution states
T cell infiltration of solid tumors is associated with favorable patient outcomes, yet the mechanisms underlying variable immune responses between individuals are not well understood.
A process called the epithelial-to-mesenchymal transition allows cancer cells to invade nearby tissue and metastasize. Katz et al.investigated the molecular underpinnings of this process and
EDITOR’S CHOICE IN CELL & MOLECULAR BIOLOGY The paper C.A. Martz et al., “Systematic identification of signaling pathways with potential to confer anticancer drug resistance,”
A key aspect of cancer metastases is the tendency for specific cancer cells to home to defined subsets of secondary organs. Despite these known tendencies,
Why does our immune system protect us so well against infection but not against cancer? In part, this is because cancer cells use clever ways
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