A strain of Staphylococcus epidermis found on human skin contains a chemical with cancer-fighting abilities, according to a study published yesterday (February 28) in Science
Scientists from Johns Hopkins, using software from Insilico Medicine, say they have invented a new class of immunotherapeutics to fight cancer. The team published its
Therapies for KRas cancers remain a major clinical need. In the current issue of Cancer Cell, Sanclemente and coworkers in Mariano Barbacid’s group validate c-Raf
Nanoscale robots have potential as intelligent drug delivery systems that respond to molecular triggers1,2,3,4. Using DNA origami we constructed an autonomous DNA robot programmed to
Using a process called in situ vaccination, in which the host’s immune system is recruited to attack cancer cells, researchers were able to clear injected
Highlights •CD10 and GPR77 define a new CAF subset •CD10+GPR77+ CAFs sustain cancer stemness and promote tumor chemoresistance •Complement signaling maintains NF-κB activation •Targeting CD10+GPR77+
Macrophages are innate immune cells that, when recruited to tumors, can promote tumor progression. Macrophage activity and phenotype can be influenced by molecules secreted by
T cell non-Hodgkin lymphomas are a heterogeneous group of highly aggressive malignancies with poor clinical outcomes1. T cell lymphomas originate from peripheral T cells and
Tumors can be divided into ‘hot’ (T cell inflamed) or ‘cold’ (T cell noninflamed) according to the presence of immune cells. In this review, we
MicroRNAs (miRNAs) regulate gene expression by inducing mRNA decay. But miRNAs can be regulated through other RNAs and DNA that bind and sequester them without
Highlights •A prospective trial reveals molecular actions of anti-PD-1 therapy •Anti-PD-1 therapy induces changes in the mutational burden of tumors •Distinct changes in gene expression
Norton Thoracic Institute researchers believe they have discovered a new approach to treating an aggressive and difficult-to-treat type of lung cancer. They published their study
Predicting responses to immunotherapy Colon cancers with loss-of-function mutations in the mismatch repair (MMR) pathway have favorable responses to PD-1 blockade immunotherapy. In a phase
Reciprocal interactions between tumor cells and their microenvironment drive cancer progression and therapy resistance. In this issue, Nabet et al. demonstrate that dynamic feedback between
A wealth cartier bracelets of evidence supports an replica cartier love bracelet association between regular physical activity (PA) and decreased risk for cancer and cancer
BACKGROUNDAmong patients with non–small-cell lung cancer (NSCLC), data on intratumor heterogeneity and cancer genome official website evolution have been limited to small retrospective cohorts. We
Detailed maps of the immune cells that surround tumours could suggest fresh therapeutic targets, point out biological markers that can be used to select the
Deep in the basement archives of London’s Great Ormond Street Hospital for Children reside the patient records that cancer researcher Sam Behjati hopes will put
Highlights •PD-L1 is primarily regulated by interferon gamma signaling in melanoma cells •PD-L2 is regulated by both interferon beta and gamma signaling •Regulation of PD-1
Therapies using T cells that are programmed to express chimeric antigen receptors (CAR T cells) consistently produce positive results in patients with hematologic malignancies. However,
The creative minds at MIT have just devised a new strategy to target and abolish cancerous tumors. In the new study—published recently in Nature Communications
Cancer is increasingly being viewed as an ecosystem, a community in which tumor cells cooperate with other tumor cells and host cells in their microenvironment.
Cancer-specific cell surface proteins can be targeted for the delivery of therapeutic agents. However, specific proteins may not always be expressed by a tumor. Wang
Type I interferons have been shown to play a major role in anti-cancer immunity. In this issue of Cancer Cell, Katlinski et al. describe tumor-induced degradation
George Klein, with his wife, Eva, discovered foundational phenomena in cancer research. He showed that normal cells carry genes, now known as tumour suppressors, that
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