Antitumour T cells stand the test of time
Immune cells called cytotoxic CD8 T cells can directly kill tumours and are key weapons mobilized in many immunotherapy approaches used in the clinic. However,
Immune cells called cytotoxic CD8 T cells can directly kill tumours and are key weapons mobilized in many immunotherapy approaches used in the clinic. However,
Teams at Helmholtz Zentrum München, LMU Munich and the Technical University of Munich (TUM) have developed a new algorithm that enables automated detection of metastases
Immune cells called CD8 (or cytotoxic) T cells can target and kill cancer cells, and immunotherapies that boost this process are in clinical use. However,
New therapies that promote antitumour immunity have been recently developed. Most of these immunomodulatory approaches have focused on enhancing T-cell responses, either by targeting inhibitory
A network of communicating tumour cells that is connected by tumour microtubes mediates the progression of incurable gliomas. Moreover, neuronal activity can foster malignant behaviour
Cancer cells have the ability to connect to and feed off of neurons in the brain, according to three studies published in Nature on Wednesday
Cancer cells usually exhibit aberrant cell signaling and metabolic reprogramming. However, mechanisms of crosstalk between these processes remain elusive. Here, we show that in an
A person’s sex can affect the kinds of cancer-causing mutations they develop, according to a genomic analysis spanning nearly 2,000 tumours and 28 types of
Many newly developed, potent cancer therapies aim to harness an immune response to target tumours1. However, a common problem with such immunotherapy approaches is the
Instructing the immune system to recognize and kill tumours, an approach termed cancer immunotherapy, has transformed the clinical treatment of certain types of malignancy. Prominent
Synthetic lethality results when mutant KRAS and EGFR proteins are co-expressed in human lung adenocarcinoma (LUAD) cells, revealing the biological basis for mutual exclusivity of
AMP-activated protein kinase (AMPK) is involved in regulating cell metabolism and is largely thought to play a suppressive role in cancer. Research by scientists at
The chemical triclosan is used as an antimicrobial agent in more than 2000 consumer products, from toothpaste and cosmetics to kitchenware and toys. Studies in
Abstract Cellular dormancy and heterogeneity in cell cycle length provide important explanations for treatment failure after adjuvant therapy with S-phase cytotoxics in colorectal cancer (CRC),
If you want to clean cancer’s clock—that is, defeat it decisively—you may want to really clean it—that is, restore it to proper working order. Only
cientists at Washington University in St. Louis say they have developed a technique employing focused ultrasound and microbubbles to release brain tumor mRNA into the
In cancer, the epithelial-to-mesenchymal transition (EMT) is associated with tumour stemness, metastasis and resistance to therapy. It has recently been proposed that, rather than being
Cancer cells signal to nontransformed cells and to other transformed cells to generate an environment that is amenable for their growth. Zhang et al. noticed
Immunotherapy represents one of the major breakthroughs in the treatment of cancer patients. Current therapies focus on harnessing the adaptive immune system, with great success
Highlights •Efficient generation of a biobank of patient-derived bladder cancer organoids •Organoids recapitulate the histological and molecular spectrum of human bladder cancer •Bladder tumor organoids
Researchers at Michigan State University say they are testing a drug that may stop a gene associated with obesity from triggering breast and lung cancer,
Identifying mutations that can be targeted to cause tumor cell death selectively in a process known as synthetic lethality has become a paradigm of cancer
Not only the number of migrating cancer cells determines the risk for metastasis but also their characteristics, scientists from the German Cancer Research Center (DKFZ)
Abstract Autophagy has been shown to be elevated in pancreatic ductal adenocarcinoma (PDAC), and its role in promoting established tumor growth has made it a
Glioblastoma, a highly malignant and usually fatal form of brain cancer, is resistant to treatment in part because it can quickly develop resistance to both
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