An immune response with a sweet tooth
Bacterial infections are a major cause of disease and death worldwide. The innate branch of the mammalian immune system, which recognizes and reacts to general
Bacterial infections are a major cause of disease and death worldwide. The innate branch of the mammalian immune system, which recognizes and reacts to general
Barrier tissue dysfunction is a fundamental feature of chronic human inflammatory diseases1. Specialized subsets of epithelial cells—including secretory and ciliated cells—differentiate from basal stem cells
One problem with the rotavirus vaccine—a preparation typically given by mouth to babies—is that it doesn’t work as well in low-income countries, where the majority
Aging is a major risk factor for melanoma. Older patients are likely to develop more aggressive disease and usually respond poorly to treatment. Kugel et
CAR-T therapies—genetically engineered T cells that destroy cancer cells—have proven to be promising options when other treatments fail. However, there’s currently no one-size-fits-all CAR T,
Immunotherapies that genetically modulate the antigenic receptors on a patient’s T cells—so-called CAR-T therapy—to seek out and destroy cancer have been met with favorable success
Immunotherapies that genetically modulate the antigenic receptors on a patient’s T cells—so-called CAR-T therapy—to seek out and destroy cancer have been met with favorable success
Highlights •High TMB correlates with efficacy of PD-1 plus CTLA-4 blockade in NSCLC •TMB and PD-L1 are independent variables •In multivariate analysis, TMB associated most
Gray hair is an inevitable part of aging. Melanocytes are the culprit cells that slow production of the color pigments called melanin, but how and
Highlights •A split, universal, and programmable (SUPRA) CAR system for T cell therapy •SUPRA CAR can fine-tune T cell activation strength to mitigate toxicity •SUPRA
A study comparing premature with full-term babies has revealed immunological differences in cord blood that suggest preterm labor may, at least in some instances, result
Highlights •A split, universal, and programmable (SUPRA) CAR system for T cell therapy •SUPRA CAR can fine-tune T cell activation strength to mitigate toxicity •SUPRA
Treating an aggressive type of lung cancer with a combination of immunotherapy and chemotherapy significantly improves patients’ survival compared with chemotherapy alone, according to a
The recent rise of pertussis in developed countries has generated controversy as to its cause. Domenech de Cellès et al. modeled pertussis transmission by using
Ovarian cancer is a particularly hard-to-treat disease. It’s often diagnosed late, and even after surgery and chemotherapy, around 85 percent of patients relapse and develop
Immunotherapy represents one of the major breakthroughs in the treatment of cancer patients. Current therapies focus on harnessing the adaptive immune system, with great success
Adult human hippocampi are home to thousands of immature neurons, researchers report today (April 5) in Cell Stem Cell. The result runs counter to a
The immune system is known for its ability to remember its response to pathogens, leading to more efficient clearance of the same pathogen upon reinfection.
Protein kinases usually propagate signals by phosphorylating substrate molecules. Goncharov et al. find a different mechanism for the protein kinase RIP2 (receptor interacting protein 2)
If the gut barrier weakens, a bacterium called Enterococcus gallinarum can leak out of the intestines, colonize the liver and other organs, and trigger a
In the mid-1950s, Sam Clark Jr. of the School of Medicine at Washington University in St. Louis looked through his electron microscope at newborn-mouse kidneys
Immune cells function by recognizing pathogens and initiating a complex cellular response to mount a defense. People can show a wide range of genetically driven
Human skin is coated with microorganisms, some of which can cause serious infection when the skin barrier is wounded. But not always. Microorganisms on all
With their pluripotency and ability to self-renew, some cancer cells have been likened to stem cells. Now, researchers show that the similarities between the cells
Camelids such as camels, llamas, and alpacas make an unusual class of antibodies with a growing number of applications in biomedical science. But researchers wanting
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