Abstract Viral whole-genome sequencing (WGS) provides critical insight into the transmission and evolution of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Long-read sequencing devices from
The CIITAdel keeps viruses at bay A better understanding of cellular mechanisms involved in viral resistance is needed for the next generation of antiviral therapies.
More than 130 million people around the globe suffer from psoriasis vulgaris, a chronic condition characterized by skin inflammation, scales, and dry patches. However, its
ABSTRACT SARS-CoV-2 is causing a second outbreak so the hope for its complete eradication is far from happening. In the absence of effective vaccines, it
Vaccine protection profile Cytomegalovirus (CMV) is a leading cause of posttransplant complications and congenital infections, but there are no CMV vaccines currently licensed. Jenks et al. characterized
Pfizer and partner BioNTech said Monday that their vaccine against Covid-19 was strongly effective, exceeding expectations with results that are likely to be met with cautious excitement
Summary Background An important feature of severe acute respiratory syndrome coronavirus 2 pathogenesis is COVID-19-associated coagulopathy, characterised by increased thrombotic and microvascular complications. Previous studies
The catastrophic global health and socioeconomic impact of COVID-19, together with the absence of any clearly effective preventive or therapeutic remedies, has created a massive
Abstract Antibodies that antagonize extracellular receptor–ligand interactions are used as therapeutic agents for many diseases to inhibit signalling by cell-surface receptors1. However, this approach does
Unlike fine wine, the human body does not improve with age. Hearing fades, skin sags, joints give out. Even the body’s immune system loses some
Failure to smell fresh cut grass or a poo-laden diaper is, at least these days, a potential sign of COVID-19 infection. “People say things smell
A recent study published in the journal Nature Medicine, led by researchers James Riley, PhD, a professor of Microbiology at the Perelman School of Medicine at
Abstract Remdesivir (RDV) is a direct-acting antiviral agent that is used to treat patients with severe coronavirus disease 2019 (COVID-19). RDV targets the viral RNA-dependent
The United States leads the world in COVID-19 deaths but lags behind many countries — both large and small — in testing capacity. That could
Whether it takes weeks, as US President Donald Trump has hinted, or months, as most health-care experts expect, an approved vaccine against the coronavirus is
The results are in from the first monoclonal antibody drug for COVID-19 tested in humans. The small Phase 2 clinical trial involving 452 participants shows
Ever since the first cases of a mysterious disease in the early 1980s exploded into the HIV/AIDS pandemic, researchers have been searching for ways to
Last month Russian President Vladamir Putin surprised the scientific community by announcing that the Russian authorities had approved the world’s first COVID-19 vaccine – Gam-COVID-19. This
Abstract Acute stroke causes complex, pathological, and systemic responses that have not been treatable by any single medication. In this study, using a murine transient
Our ability to keep HIV under control has been revolutionized by antiretroviral therapy (ART). But ART is not a cure — the HIV genome can
Doctors have reported the first confirmed cases of individuals who have tested positive for SARS-CoV-2 infection a second time. The first report was of a patient
Highlights 1.Acute phase SARS-CoV-2-specific T cells display an activated cytotoxic phenotype 2.Broad and polyfunctional SARS-CoV-2-specific T cell responses in convalescent phase 3.Detection of SARS-CoV-2-specific T
rthritis affects almost 2% of the world’s population, or some 150 million people, and currently, there is no completely effective treatment for this chronic disease.
An experimental vaccine is effective at preventing pneumonia in mice infected with the COVID-19 virus, according to a study from Washington University School of Medicine
Psoriasis, a chronic skin condition that causes itchy, red, scaly patches, afflicts more than 8 million Americans and 125 million people worldwide. Small molecule-based drugs
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