The self-correcting nature of science has always seemed enigmatic to the uninitiated and armchair scientists. Yet, independent reproducibility is a hallmark of the proper scientific
A new way of inducing pluripotency has been demonstrated by scientists based at the Gladstone Institutes. Rather than fuss with the usual transcription factors or
Doctors at the University of Pennsylvania posted plans for a clinical trial, which will combat cancer using human immune cells reprogrammed with CRISPR, on ClinicalTrials.gov
The body’s own immune system could thwart some efforts to develop gene therapies based on the trendy genome-editing tool called CRISPR-Cas9, according to a study
Base editing is a relatively recent genome-editing technique that swaps one DNA base pair for another, offering researchers the potential to correct harmful, single-nucleotide mutations
Fusing an RNA-editing enzyme to an RNA-targeting Cas protein has enabled researchers to edit specific nucleotides within RNA molecules in human cells. The approach, called
A signature event for organoids Human cancer genomes harbor cryptic mutational signatures that represent the cumulative effects of DNA damage and defects in DNA repair
In May 2012, the University of California, Berkeley, filed a patent application for biochemist Jennifer Doudna and the University of Vienna’s Emmanuelle Charpentier, then of
CRISPR, the wildly popular genome-editing research tool, was invented in the West, but it is speeding toward potential human applications in China. Last week, the
A team of Chinese researchers who were the first to report having applied CRISPR to human embryos have done it again—this time upgrading their technique
Scientists have used the gene-editing CRISPR-Cas9 system to suppress the gene encoding the protein OCT4 in experiments with human embryos. According to the results, published
In a seminal study published earlier this month in Nature, researchers used CRISPR gene-editing technology to repair a heart-disease inducing genetic mutation in human embryos.
Highlights •Phage-encoded anti-CRISPRs (Acrs) inhibit CRISPR-Cas9 through unique mechanisms •AcrIIC1 controls genome editing by diverse Cas9 orthologs •AcrIIC1 binding disables Cas9’s nucleases without impacting DNA
Armed with a modified version of CRISPR-Cas9, scientists have removed nucleotide repeats from RNA in vitro that are known to cause diseases, namely, Huntington’s, ALS,
Last week, word got out that a team of scientists had edited viable human embryos for the first time in the United States. Details of
The most abundant biological entities on Earth still have a few tricks up their sleeve, and a recent surge of research is reinvigorating the field.
Cryo-electron microscopy (Cryro-EM) molecular mapping was used to determine how the bacterial gene editing complex CRISPR/Cas9 interacts with viral anti-CRISPR proteins. CRISPRs (clustered regularly interspaced
Researchers have been studying the CRISPR-Cas9 gene-editing system as a potential therapeutic tool to modify or delete pathogenic sequences within the human genome. Now, using
Identification of effective combination therapies is critical to address the emergence of drug-resistant cancers, but direct screening of all possible drug combinations is infeasible. Here
A protein thought to be essential for cancer cells may not be so essential after all, according to a study published today (March 24) in
In early 2012, Emmanuelle Charpentier, a little-known French microbiologist who would soon meet worldwide fame, contacted her old friend Rodger Novak to tell him about
With over 10 million active cases in 2015 and close to 2 million deaths, tuberculosis (TB) remains a leading cause of death worldwide. Moreover, the
A very focused function for lncRNAs The human genome generates many thousands of long noncoding RNAs (lncRNAs). A very small number of lncRNAs have been
Microbes use a number of CRISPR-Cas systems for immunity, but it’s the class 2 system, typically utilizing the nuclease Cas9, that has been adapted for
Two ongoing disputes brought The Scientist to the courtroom to listen in on the proceedings this year. The first is a defamation suit that former
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