Abstract Mismatch repair-deficient (MMRd) cancers have varied responses to immune checkpoint blockade (ICB). We conducted a phase 2 clinical trial of the PD-1 inhibitor pembrolizumab
Abstract Locally advanced pancreatic tumours are highly resistant to conventional radiochemotherapy. Here we show that such resistance can be surmounted by an injectable depot of
Abstract In pursuit of treating Parkinson’s disease with cell replacement therapy, differentiated induced pluripotent stem cells (iPSC) are an ideal source of midbrain dopaminergic (mDA)
Abstract Large segmental osseous defects heal poorly. Recombinant, human bone morphogenetic protein-2 (rhBMP-2) is used clinically to promote bone healing, but it is applied at
A few weeks after receiving an experimental cancer therapy that turns immune cells into tumour-killing hunters, Doug Olson’s doctor sat him down to give him
Abstract Zika virus (ZIKV) is a mosquito-borne arbovirus that can cause severe congenital birth defects. The utmost goal of ZIKV vaccines is to prevent both
Abstract The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the pandemic of the coronavirus induced disease 2019 (COVID-19) with evolving variants of concern.
A new injectable therapy harnesses “dancing molecules” to reverse paralysis and repair tissue after severe spinal cord injuries. When just a single injection was administered
The gene editor CRISPR excels at fixing disease mutations in lab-grown cells. But using CRISPR to treat most people with genetic disorders requires clearing an
The mitogen-activated protein kinase (MAPK) pathway is an important bridge in the switch from extracellular signals to intracellular responses. Overactivation of the MAPK pathway is
The catastrophic global health and socioeconomic impact of COVID-19, together with the absence of any clearly effective preventive or therapeutic remedies, has created a massive
Ever since the first cases of a mysterious disease in the early 1980s exploded into the HIV/AIDS pandemic, researchers have been searching for ways to
An experimental vaccine is effective at preventing pneumonia in mice infected with the COVID-19 virus, according to a study from Washington University School of Medicine
Head and neck squamous cell carcinoma (HNSCC) develops in the mucous membranes of the mouth, nose, and throat. It is an aggressive life-threatening disease associated
One extremely frustrating aspect of cancer researcher and treatment is that some forms of cancer have no effective treatment options. Metastatic rhabdomyosarcoma, a form of
A major phase III trial of capivasertib, a cancer drug discovered following collaborative work between The Institute of Cancer Research, London, and partners, has begun
In a press release on Tuesday (June 16), researchers from a large, randomized controlled trial for COVID-19 treatments announced that they’d seen an improvement in survival at
Abstract Techniques for exclusion of exons from mature transcripts have been applied as gene therapies for treating many different diseases. Since exon skipping has been
A novel type of killer T cell has been identified as a potential universal cancer therapy. The most widely used T-cell therapy, CAR T, is
A novel drug based on a natural compound found in broccoli, kale and other cruciferous vegetables could hold the key to reversing or even preventing
For decades, research into Alzheimer’s disease has centred on neurons. Only in the past few years have scientists identified a role for immune cells in
Antibodies with specificity for one target — called monoclonal antibodies — were the first cancer immunotherapy to achieve widespread clinical use. The therapeutic potency of
People with a rare form of inherited blindness are being enrolled for the world’s first in vivo study of a CRISPR-based therapy, the Associated Press
Supporting tumor suppression The protein PTEN is a phosphatase and tumor suppressor whose activity is often decreased in human cancers. Thus, reactivating such a protein
Researchers report in Science that indole-3-carbinol (I3C) – a natural compound found in broccoli – can be used to therapeutically target a gene (WWP1) known
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