Long regarded as a biological aberration, amyloids are fibrous aggregates of short protein fragments. Amyloids have a bad reputation because they are thought to be
Camelids such as camels, llamas, and alpacas make an unusual class of antibodies with a growing number of applications in biomedical science. But researchers wanting
Alterations in the metabolism of the neuronal microtubule-associated protein tau are central to several neurodegenerative diseases. In these diseases, tau usually loses solubility and forms
Highlights •Trim-Away is a widely applicable method to degrade endogenous proteins •Target proteins do not need to be modified before degradation •Proteins are degraded within
A powerful new way of analysing how drugs interact with molecules in the body could aid the design of better treatments with fewer side-effects. Most
Cryo-electron microscopy (Cryro-EM) molecular mapping was used to determine how the bacterial gene editing complex CRISPR/Cas9 interacts with viral anti-CRISPR proteins. CRISPRs (clustered regularly interspaced
Cancer-specific cell surface proteins can be targeted for the delivery of therapeutic agents. However, specific proteins may not always be expressed by a tumor. Wang
Detection of viral RNAs causes oligomerization of mitochondrial antiviral signaling (MAVS) protein, which leads to the production of type I interferons (IFNs). Buskiewicz et al.
It has been 8 years since an astonishing observation persuaded many scientists that the misfolded protein implicated in Parkinson’s disease spreads from brain cell to
It has been 8 years since an astonishing observation persuaded many scientists that the misfolded protein implicated in Parkinson’s disease spreads from brain cell to
Researchers at the Gladstone Institutes and several other institutions say they have discovered that changing a specific part of the huntingtin protein prevented the loss
A new study led by investigators at the University of Glasgow has identified how cells protect themselves against misfolded and aggregated proteins known to be
A variety of debilitating neuro-degenerative diseases are caused by the defective folding of particular proteins. A case in point is amyotrophic lateral sclerosis (ALS or
Cancer researchers have linked development of resistance to the anticancer drug temozolomide by glioblastoma multiforme (GBM) brain cancer cells to the activity of the RhoG-specific
The allele apolipoprotein E ε4 (APOE ε4) is the greatest genetic risk factor for Alzheimer’s disease (AD), but the role of the ApoE4 protein in
The hunt for the fountain of youth is back to square one — at least for those seeking it in blood. New findings cast doubt
The hunt for the fountain of youth is back to square one — at least for those seeking it in blood. New findings cast doubt
The completion of the human genome sequence more than a decade ago was an indisputable triumph for biomedical research. And more recently, efforts such as
Created by ePubSystems. Contact Us for similar site for your university or institute.