Highlights •Loss of CAST/ELKS reduces presynaptic CaV2.1 currents and channels •Deletion of CAST/ELKS increases Pr, spontaneous release, while reducing RRP size •CAST/ELKS are positive regulators
Changes in gut bacteria have been linked with the development of age-related disorders and chronic diseases, and research suggests that targeting the microbiome as part
Highlights Class A GPCRS exist in monomer–dimer equilibrium. Monomeric class A GPCRs effectively activate G proteins, are phosphorylated by GRKs, and bind arrestins. GPCR oligomers
Highlights •Nitric oxide binds to the staphylococcal virulence regulator AgrA •S-nitrosylation of AgrA inhibits staphylococcal virulence •Nitric oxide is protective in a murine pneumonia model
Humans like to fancy ourselves advanced, but there’s at least one area where cockroaches, and even nematodes, seem to have us beat: magnetoreception, the ability
Humans like to fancy ourselves advanced, but there’s at least one area where cockroaches, and even nematodes, seem to have us beat: magnetoreception, the ability
Humans like to fancy ourselves advanced, but there’s at least one area where cockroaches, and even nematodes, seem to have us beat: magnetoreception, the ability
Long regarded as a biological aberration, amyloids are fibrous aggregates of short protein fragments. Amyloids have a bad reputation because they are thought to be
Highlights •Treatment of cells with NAC leads to mitochondrial sulfane sulfur production •Redox-sensitive GFP can be used to monitor persulfide generation in living cells •Sulfane
Unravel a bacterial survival strategy that they term “density-dependent persistence” or DDP. The authors demonstrate that the majority of isogenic cells in bacterial populations survive
Tuberculosis is no longer on the LAM Lipoarabinomannan (LAM) is a component of the cell wall shed by Mycobacterium tuberculosis, the bacteria responsible for tuberculosis,
A century after they were discovered killing diarrhea-causing bacteria in the feces of World War I soldiers, the viruses known as bacteriophages, or simply phages,
A synthetic base pair, first reported in 2014, can now not only replicate inside living cells, but also encode and produce proteins containing atypical amino
Blowflies and houseflies are mechanical vectors inhabiting synanthropic environments around the world. They feed and breed in fecal and decaying organic matter, but the microbiome
Abstract Sulfonylureas are anti-diabetic medications that act by inhibiting pancreatic KATP channels composed of SUR1 and Kir6.2. The mechanism by which these drugs interact with
Highlights •Different EGFR ligands stabilize receptor dimers with distinct structures •Epiregulin and epigen induce weaker and more short-lived EGFR dimers than EGF •Weakened dimerization causes
A team of molecular microbiologists used quantum dot technology to increase the efficacy of antibiotics to the point where they became capable of killing strains
The Nobel Prize in Chemistry was awarded this morning (October 4) to three scientists who developed cryo-electron microscopy, a method that allows scientists to freeze
Tracking 265 people’s various microbial communities, researchers have provided a wealth of data on microbiome variation across the body and over time. As part of
The most abundant biological entities on Earth still have a few tricks up their sleeve, and a recent surge of research is reinvigorating the field.
Highlights •Identification of more than ten small-molecule proteasome activators •Proteasome activators increase degradation of model substrates •P38 MAPK inhibition increases the clearance of toxic α-synuclein
With the world facing an anti-biotic-resistance crisis, the hunt is on for alternatives to fight bacterial infection. The quest has led peptide chemist Barney Bishop
As many as 8 percent of pregnant women develop a condition known as preeclampsia, a spike in blood pressure characterized by the reduced formation of
Adenosine triphosphate (ATP) is the canonical energy carrier that powers cellular machines, drives metabolic reactions, and serves as a precursor to nucleic acids. On page
The importance of delivery method for the development of babies’ gut bacteria has come into question in recent months. A new study from University of
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