The excitatory neurotransmitter glutamate induces modulatory actions via the metabotropic glutamate receptors (mGlus), which are class C G protein–coupled receptors (GPCRs). We determined the structure
In Kurt Vonnegut’s Cat’s Cradle, scientists create a highly stable form of crystalline water called “ice-nine” that stays frozen even at high temperatures. Ice-nine instantly freezes
Platelets, known for slowing bleeding upon injury, may also play a key role in immunity, according to a new study that found platelets in the
High-grade gliomas are extremely difficult to treat because they are invasive and therefore not curable by surgical resection; the toxicity of current chemo- and radiation
Using proteomics in combination with a 19th-century surgical technique in which the circulatory systems of two mice are joined together, researchers have demonstrated that a
Pyruvate kinase isoform M2 (PKM2) is a glycolysis enzyme catalyzing conversion of phosphoenolpyruvate (PEP) to pyruvate by transferring a phosphate from PEP to ADP. We
The biguanide drug metformin is widely prescribed to treat type 2 diabetes and metabolic syndrome, but its mode of action remains uncertain. Metformin also increases
Organisms respond to DNA damage by one of two cellular coping mechanisms: they either repair the genomic injury or destroy the damaged cells through a
A nanocomplex of enzymes can lower blood alcohol levels and reduce liver damage in intoxicated mice, according to a study published today (February 17) in Nature
Changes in the microbial community structure are observed in individuals with intestinal inflammatory disorders. These changes are often characterized by a depletion of obligate anaerobic
Febrifugine is the active component of the Chinese herb Chang Shan (Dichroa febrifuga Lour.)1, 2, which has been used for treating malaria-induced fever for about 2,000 years. Halofuginone
A species of bacterium forms tiny nuggets of gold to combat the toxic effects of the dissolved form of the element. The bacterium Delftia acidovorans lives in
Nature 480, 254–258 ( 2011); DOI: 10.1038/nature10575. John C. Tran, Leonid Zamdborg, Dorothy R. Ahlf, Ji Eun Lee, Adam D. Catherman, Kenneth R. Durbin, Jeremiah
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