The importance of delivery method for the development of babies’ gut bacteria has come into question in recent months. A new study from University of
Some pathogens block generation of reactive oxygen species to evade neutrophil killing, but how that is accomplished is poorly understood. In this issue of Cell
Safe anaerobic metabolism Naked mole-rats live in large colonies deep underground in hypoxic conditions. Park et al. found that these animals fuel anaerobic glycolysis with
Cryo-electron microscopy (Cryro-EM) molecular mapping was used to determine how the bacterial gene editing complex CRISPR/Cas9 interacts with viral anti-CRISPR proteins. CRISPRs (clustered regularly interspaced
Resistance on a background of tolerance Bacteria survive antibiotic exposure either because they are quiescent when antibiotics are around in the highest concentrations (i.e., tolerance)
Bacteria use two strategies to avoid being killed by antibiotics: resistance and tolerance. Resistance mechanisms such as destruction of a drug or modification of its
Determining the biological consequences of the thousands of genetic variants that contribute to common diseases is challenging. Genetic variants that influence autoimmune diseases have been
Determining the biological consequences of the thousands of genetic variants that contribute to common diseases is challenging. Genetic variants that influence autoimmune diseases have been
Quantitation of metabolic pathway regulation Although metabolic biochemical pathways are well understood, less is known about precisely how reaction rates or fluxes through the various
A small fraction of proteins have an unusual conformation in which the backbone forms a knot. An example is a bacterial enzyme, TrmD, that transfers
The ice plant thrives in salty ocean-side mist. Barkla et al. used proteomics to identify proteins in these halophytes that are critical to the defense
A variety of debilitating neuro-degenerative diseases are caused by the defective folding of particular proteins. A case in point is amyotrophic lateral sclerosis (ALS or
We live in a world flooded with light 24 hours a day. Before our recent harnessing of electricity, light was a reliable indicator of seasonal
Highlights •Tumor cell metabolic flexibility enables glucose-independent cell proliferation •PCK2 helps generate glycolytic intermediates under low-glucose conditions •PCK2 expression is regulated by glucose and required
Years after Elizabeth Blackburn, Ph.D. won the Nobel Prize for her seminal work on the molecular nature of telomeres and co-discovery of the ribonucleoprotein enzyme
Move over, poppies. In one of the most elaborate feats of synthetic bio logy to date, a research team has engineered yeast with a medley
The hunt for the fountain of youth is back to square one — at least for those seeking it in blood. New findings cast doubt
The hunt for the fountain of youth is back to square one — at least for those seeking it in blood. New findings cast doubt
The ability of the bizarre prion protein to cause an array of degenerative brain conditions may help solve a puzzle in Alzheimer’s research why the
The completion of the human genome sequence more than a decade ago was an indisputable triumph for biomedical research. And more recently, efforts such as
Osteoclasts are cells that break down bone; however, excessive bone loss leads to conditions such as osteoporosis. When three proteins called RANKL bind to three
Two studies provide evidence that the protein complex PTEX is needed for export of malaria-parasite proteins into the cytoplasm of infected cells, and that such
A cellular stress pathway called the unfolded-protein-response (UPR) both activates and degrades death receptor 5 protein (DR5), which can promote or prevent cell suicide, according
Patrick Harran, a chemist at the University of California, Los Angeles, will pay $10,000, develop and teach a lab-safety course, speak about the importance of
On an otherwise ordinary day in 1964,Bruce Ames picked up a box of potato chips and read the list of ingredients. A biochemist at the National
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