Highlights Primary human testicular cells form organoids regardless of scaffold support The testis-specific cytoarchitecture was not restored in testicular organoids Active niche cells and spermatogonia
The role of RAS dimerization in tumor biology is an emerging area of preclinical cancer research. Characterization of a RAS monobody indicates that dimer formation
ukaryotic cells store their DNA in the nucleus, cordoned off from the cytoplasm by the nuclear envelope. Made up of two lipid bilayers called the
It has been 8 years since an astonishing observation persuaded many scientists that the misfolded protein implicated in Parkinson’s disease spreads from brain cell to
It has been 8 years since an astonishing observation persuaded many scientists that the misfolded protein implicated in Parkinson’s disease spreads from brain cell to
Highlights •GOLM1 is identified as a leading gene relating to HCC metastasis •GOLM1 is correlated to early metastatic recurrence and poor survival of HCC patients
Increasing the levels of therapeutic proteins in vivo remains challenging. Antisense oligonucleotides (ASOs) are often used to downregulate gene expression1 or to modify RNA splicing2,
Chromatin structure stabilizes and compacts the genome to package it within the nucleus. This structure also serves as a dynamic regulator of gene expression, silencing
The non-receptor protein tyrosine phosphatase SHP2, encoded by PTPN11, has an important role in signal transduction downstream of growth factor receptor signalling and was the
Working out is good for the brain. Now, a team of scientists from the U.S. and Germany has a clearer idea why. A protein called
Multiple sclerosis (MS) is an autoimmune disorder characterized by T cell-mediated demyelination and neurodegeneration in the CNS (Friese and Fugger, 2005, Pender and Greer, 2007, Sospedra
Researchers at the US National Cancer Institute (NCI) have successfully visualized the structures of enzymes at near-atomic resolutions previously not considered possible, using cryo-electron microscopy
The ice plant thrives in salty ocean-side mist. Barkla et al. used proteomics to identify proteins in these halophytes that are critical to the defense
The White House today (May 13) announced the launch of a National Microbiome Initiative to support research on the microorganisms that live in or on
RNA consists of a phosphate backbone, sugar, and four bases (A, U, C, G), and has long seemed a promising candidate for early life’s precursor,
Scientists at the Gladstone Institutes have discovered how the major genetic risk factor for Alzheimer’s disease causes memory impairment. A specific type of brain activity
Scientists at the Gladstone Institutes have discovered how the major genetic risk factor for Alzheimer’s disease causes memory impairment. A specific type of brain activity
A newly discovered pathway leading to neurodegeneration in Alzheimer’s disease (AD) may unlock the door to new approaches for treating the disease. The findings, published
A newly discovered pathway leading to neurodegeneration in Alzheimer’s disease (AD) may unlock the door to new approaches for treating the disease. The findings, published
Researchers at the Vollum Institute in Portland, Oregon, have resolved the crystal structures of the human serotonin transporter (SERT) bound to two different antidepressant drugs.
Apoptosis, necrosis, and pyroptosis The routes to cell death are many, and distinguishing which path a particular cell may have taken remains a challenge. Wallach
A team of researchers from Israel and the U.S. has developed the first lines of human, haploid embryonic stems cells, according to a study published
Many tissues harbor a reservoir of stem cells that remains quiescent but can be activated as needed for growth and repair. How cells enter, maintain,
Androgen deprivation therapy (ADT) has been the standard of care for management of metastatic prostate cancer for more than 70 years. Its use in locally
The RNA-guided endonuclease Cas9 is a versatile genome-editing tool with a broad range of applications from therapeutics to functional annotation of genes. Cas9 creates double-strand
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