Highlights • Maternal fiber deprivation lastingly and detrimentally influenced microbiome of offspring• Maternal fiber deprivation resulted in low-grade gut inflammation in offspring• Offspring of fiber-deprived
Abstract Proton transfer between the DNA bases can lead to mutagenic Guanine-Cytosine tautomers. Over the past several decades, a heated debate has emerged over the
Highlights Longitudinal glioma evolution follows an IDH mutation-dependent trajectory• Hypermutation and CDKN2A deletions underlie increased proliferation at recurrence• Recurrent IDH-wild-type neoplastic cells up-regulate neuronal signaling programs• Mesenchymal
Highlights •Microbial recognition activates myeloid calcineurin and NFAT in colorectal cancer •NFAT-dependent IL-6 promotes expression of co-inhibitory B7H3 and B7H4 by tumors •B7H3/B7H4 inhibit CD8+ T cells
Highlights •Microbial recognition activates myeloid calcineurin and NFAT in colorectal cancer •NFAT-dependent IL-6 promotes expression of co-inhibitory B7H3 and B7H4 by tumors •B7H3/B7H4 inhibit CD8+ T cells
Significance Although the need for a universal influenza vaccine has long been recognized, only a handful of candidates have been identified so far, with even
Highlights •The N terminus of ApoE binds to PIPs and TAG in an isoform-specific manner •Lean astrocytes secrete cholesterol-loaded ApoE; this is unaffected by polymorphism
Abstract HIV is difficult to eradicate due to the persistence of a long-lived reservoir of latently infected cells. Previous studies have shown that natural killer
T cells to fix a broken heart Making CAR T cells in vivo Abstract Acknowledgments Supplementary Materials References and Notes 0eLetters Making CAR T cells
Abstract Misfolding and aggregation of alpha-synuclein (αS) within dopaminergic neurons is a key factor in the development and progression of a group of age-related neurodegenerative
Significance Alongside αβ T cells and B cells, γδ T cells comprise a major component of the adaptive immune system, although a lack of bona
Highlights •MTHFD2 is critical for activated CD4 T cells to maintain de novo purine synthesis •Insufficient MTHFD2 promotes Treg cell-like phenotypes and metabolism in Th17 cells •Inhibition of
Abstract Glutathione (GSH) is a small-molecule thiol that is abundant in all eukaryotes and has key roles in oxidative metabolism1. Mitochondria, as the major site
Abstract A proteomics tool capable of identifying single proteins would be important for cell biology research and applications. Here, we demonstrate a nanopore-based single-molecule peptide
Highlights • Mitochondria in the mouse brain are long lived and show considerable age mosaicism• Mitochondria contain many LLPs as part of protein complexes• LLPs
Significance Dry age-related macular degeneration (AMD) affects the vision of millions of people worldwide. There is currently no Food and Drug Administration–approved treatment for dry
Highlights •We investigate the relationship of patient age and ICB therapy biomarkers •Favorable ICB biomarkers are generally more prevalent in elderly patients •The CAMA web
Abstract Methodologies for the controlled delivery of genetic information into target cells are of utmost importance for genetic engineering in both fundamental and applied research.
Infection with the SARS-CoV-2 virus can lead to diverse outcomes, ranging from no symptoms to varying degrees of disease severity, spanning mild illness to death.
SARS-CoV-2 is no Ferrari among viruses when it comes to mutations. Scientists reckon that its 30,000-base RNA genome acquires around two single-letter mutations a month, a rate
Astrocytes are glial cells that are abundant in the central nervous system (CNS) and that have important homeostatic and disease-promoting functions1. However, little is known
Abstract Introduction: Aging is characterized by the progressive loss of physiological capacity. At the cellular level, two key hallmarks of the aging process include telomere
Failure to smell fresh cut grass or a poo-laden diaper is, at least these days, a potential sign of COVID-19 infection. “People say things smell
Abstract Modern development of flexible electronics has made use of bioelectronic materials as artificial tissue in vivo. As hydrogels are more similar to nerve tissue, functional
When COVID-19 spread around the globe this year, David Montefiori wondered how the deadly virus behind the pandemic might be changing as it passed from
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