Highlights •Trim-Away is a widely applicable method to degrade endogenous proteins •Target proteins do not need to be modified before degradation •Proteins are degraded within
Summary By sequencing and comparing hundreds of bacterial genomes, researchers have shown that all of the explosive epidemics of cholera in Africa and the Americas
Summary By sequencing and comparing hundreds of bacterial genomes, researchers have shown that all of the explosive epidemics of cholera in Africa and the Americas
Cells respond to metabolic fluctuations by adjusting the speed of DNA replication as a safeguard for genome stability. Somyajit et al. elucidate the cellular mechanisms
When Neandertals mated with modern humans, they shared more than an intimate moment and their own DNA. They also gave back thousands of ancient African
One day in 2006, while a postdoc in the Rockefeller University laboratory of Nathaniel Heintz, I had an unexpected eye-opener. Heintz showed me some electron
The most abundant biological entities on Earth still have a few tricks up their sleeve, and a recent surge of research is reinvigorating the field.
For almost a century, Neandertals were considered the ancestors of modern humans. But now, in a new plot twist in the unfolding mystery of how
Deep in the basement archives of London’s Great Ormond Street Hospital for Children reside the patient records that cancer researcher Sam Behjati hopes will put
From the dry valleys of Antarctica to the depths of a Welsh coal mine, a promised revolution in genome sequencing may finally be catching fire.
Rapid and simple assays to detect infectious agents are key to tracking emerging epidemics. Chotiwan et al. describe a loop-mediated amplification (LAMP) assay that detects
Cryo-electron microscopy (Cryro-EM) molecular mapping was used to determine how the bacterial gene editing complex CRISPR/Cas9 interacts with viral anti-CRISPR proteins. CRISPRs (clustered regularly interspaced
In early 2012, Emmanuelle Charpentier, a little-known French microbiologist who would soon meet worldwide fame, contacted her old friend Rodger Novak to tell him about
When is a mutation a true genetic variant? Large-scale sequencing studies have set out to determine the low-frequency pathogenic genetic variants in individuals and populations.
Scientists at Dartmouth’s Norris Cotton Cancer Center (NCCC) say they have identified the functional role of two distinct DNA modifications in glioblastoma (GBM) tissues. The
Spontaneously arising de novo mutations are likely important contributors to the development of autism spectrum disorder (ASD) in affected individuals. Genetic mutation is an ongoing
The activated spliceosome (Bact) is in a catalytically inactive state and is remodeled into a catalytically active machine by the RNA helicase Prp2, but the
The term “life hacking” usually refers to clever tweaks that make your life more productive. But on p. 819, a team of scientists comes a
Near Eastern genomes from Iran The genetic composition of populations in Europe changed during the Neolithic transition from hunting and gathering to farming. To better
The vast majority of genes in sexually reproducing eukaryotes can recombine during the production of gametes. This reshuffling generates new genotypes that may provide selective
Evolution has seen fit to impart our genetic code with residual sequences that until recently were thought of as mere anomalies with no apparent biological
Today being the 207th birthday celebration of renowned naturalist and evolutionary biologist Charles Darwin, it seemed only appropriate to discuss the recent findings of how
Are you the type of person that jumps out of bed bright-eyed and ready to take on the world? If so, your early morning cheeriness
It is increasingly common practice for researchers to scan DNA sequence data from tumor biopsies of cancer patients—the idea being that the presence of mutations
Retroviral sequences in mammalian genomes are the remnants of old viral infections and, for the most part, their expression is suppressed. But a report published
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