The results of the first clinical trial using induced pluripotent stem cells from donors point to signs of efficacy for treating the progressive form of
Highlights • Glioma stem cells home toward, invade, and proliferate in human cerebral organoids • GLICO (cerebral organoid glioma) tumors phenocopy patient glioblastoma • Tumor
A person with HIV seems to be free of the virus after receiving a stem-cell transplant that replaced their white blood cells with HIV-resistant versions.
For the second time, a person living with HIV appears to have cleared the virus after a stem cell transplant replaced his infected immune cells
Among stem cell policy changes instituted since U.S. President Barack Obama took office, the National Institutes of Health (NIH) made a linkurl:controversial move;http://www.the-scientist.com/blog/display/57274/ to not
Among stem cell policy changes instituted since U.S. President Barack Obama took office, the National Institutes of Health (NIH) made a linkurl:controversial move;http://www.the-scientist.com/blog/display/57274/ to not
Scientists have for the first time grown functioning human blood vessel organoids from stem cells in the lab. Their study, published on Wednesday (January 16)
Over the past five years, various studies have shown that mouse and human stem cells can spontaneously organize in a dish into 3D structures that
Breast tissue undergoes a remarkable transformation to allow for breastfeeding—and the process reverses after weaning. Lipid-filled fat cells essentially disappear to make room for milk
The sleep disorder narcolepsy is linked to immune-system genes and is caused by the loss of neurons that express the protein hypocretin. Hypocretin-targeting immune cells
Contrary to previous assumptions, it seems the cells that line blood vessels are derived from more than one source. In addition to their known developmental
Pluripotent cells have been used to probe developmental pathways that are involved in genetic diseases and oncogenic events. To find new therapies that would target
CAR-T therapies—genetically engineered T cells that destroy cancer cells—have proven to be promising options when other treatments fail. However, there’s currently no one-size-fits-all CAR T,
Summary Restoration of insulin independence and normoglycemia has been the overarching goal in diabetes research and therapy. While whole-organ and islet transplantation have become gold-standard
Abstract Most of the hematopoietic stem cells (HSCs) within the bone marrow (BM) show quiescent state with a low mitochondrial membrane potential (ΔΨm). In contrast,
Stem cell-based clinical interventions are increasingly advancing through preclinical testing and approaching clinical trials. The complexity and diversity of these approaches, and the confusion created
SETD2encodes a histone H3 lysine 36 (H3K36) methyltransferase affected by mutations and deletions in a wide variety of cancers. WhetherSETD2loss alone can initiate tumorigenesis has
A pharmaceutical company based in Osaka, Japan, opened a regenerative medicine center yesterday (March 22) that will produce cells derived from induced pluripotent stem (iPS)
With their pluripotency and ability to self-renew, some cancer cells have been likened to stem cells. Now, researchers show that the similarities between the cells
Multipotent stromal cells have long been a hot topic in medical research. Scientists at the University of Bonn have now found a way to specifically
A new way of inducing pluripotency has been demonstrated by scientists based at the Gladstone Institutes. Rather than fuss with the usual transcription factors or
Highlights •Somatic cell nuclear transfer (SCNT) using fetal fibroblasts yielded two live monkeys •Epigenetic modulators promoted development and pregnancy rate of SCNT embryos •SCNT using
The promise of cell-based therapy is limited by the challenge of generating large enough numbers of the correct type of cells. But a strategy called
Nanoparticles designed to selectively deliver the drug niclosamide to cancer stem cells caused the cancer stem cells to lose their stem-like properties and rendered them
Highlights •NOTCH signaling is preferentially activated in glioblastoma stem cells •GSIs have limited activities against glioblastoma stem cells •FTIs improve response to GSIs in vitro
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