Muscle repair without stem cells Skeletal muscle is a mechanical organ that endures cellular damage after contraction. Lesions caused by external injury can be repaired
Highlights •ApoE4 ACM induces neuronal lipid raft expansion and Aβ42 overproduction •Co-localization of lipid rafts and APP increases in neurons by ApoE4 ACM •Increasing cholesterol in
Abstract Naive human pluripotent stem cells (hPSCs) can be used to generate mature human cells of all three germ layers in mouse–human chimeric embryos. Here,
Abstract Driver mutations in genes encoding histone H3 proteins resulting in p.Lys27Met substitutions (H3-K27M) are frequent in pediatric midline brain tumors. However, the precise mechanisms
The tumour suppressor APC is the most commonly mutated gene in colorectal cancer. Loss of Apc in intestinal stem cells drives the formation of adenomas in mice via increased
Abstract Short-term, systemic expression of the Yamanaka reprogramming factors (Oct-3/4, Sox2, Klf4 and c-Myc [OSKM]) has been shown to rejuvenate aging cells and promote tissue regeneration in vivo. However, the
Highlights •A human stem cell-derived organoid model of widespread and compact myelination •Recapitulated impaired paranode formation in patient-derived cultures •Pharmacological modulation of oligodendrocyte morphology and
Highlights • CSCs use CD276 to evade immune surveillance in SCC initiation and metastasis• CD276 is a functional cell surface marker to isolate CSCs from
Abstract Induced pluripotent stem cells (iPSCs) are an established cellular system to study the impact of genetic variants in derived cell types and developmental contexts.
Highlights • Lamin B1 is downregulated with age in neural stem cells (NSCs)• SUN1 protein levels increase in aged NSCs• Lamin B1 and SUN1 modulate
Zoning in on liver growth For organ homeostasis or regrowth after injury or disease, one or more stem cell populations is needed to rebuild lost
Abstract Terminally differentiated murine osteocytes and adipocytes can be reprogrammed using platelet-derived growth factor–AB and 5-azacytidine into multipotent stem cells with stromal cell characteristics. We
Highlights •Generation of hiPS cell-derived 3D spheroids resembling the hindbrain/spinal cord •Synaptically connected corticofugal projections in fused cortico-spinal assembloids •Stimulation of cortical neurons controls skeletal
Abstract Neural stem cells (NSCs) generate neurons throughout life in the mammalian hippocampus. However, the potential for long-term self-renewal of individual NSCs within the adult
Researchers at EPFL have developed an approach to print tiny tissues that look and function almost like their full-sized counterpart. Measuring just a few centimeters
Significance Transfer of sperm-producing stem cells isolated from a donor male into testes of a recipient male has important applications for preserving germplasm and as
Adult heart muscle cells (cardiomyocytes) cannot regenerate after ischemic injury. However, neonatal cardiomyocytes do regenerate. Cui et al. undertook single-nucleus RNA sequencing of cardiomyocytes to find out
Definitive haematopoiesis in the fetal liver supports self-renewal and differentiation of haematopoietic stem cells and multipotent progenitors (HSC/MPPs) but remains poorly defined in humans. Here,
Tucked away in Tokyo’s trendiest fashion district — two floors above a pricey French patisserie, and alongside nail salons and jewellers — the clinicians at
Cortical organoids—three-dimensional bundles of neurons and glia grown in a dish from induced pluripotent stem cells—look a lot like tiny brains. And while the gene
In a healthy adult, tissue-specific stem cells replenish damaged tissue and sustain plasticity (the addition of new cells) in organs. In two regions of the
An “off-the-shelf” cell therapy derived from induced pluripotent stem cells (iPSCs) has entered clinical trials in the United States. Other companies are following suit, harnessing
Researchers have managed to grow large numbers of blood-forming stem cells in the lab using a surprisingly simple ingredient found in glue. And when injected
In mice whose sense of smell has been disabled, a squirt of stem cells into the nose can restore olfaction, researchers report today (May 30)
Highlights • Gata3, Eomes, Tfap2c, Myc, and Esrrb convert fibroblasts into iPSCs, iTSCs, and iXENs • Esrrb, but not other pluripotency genes, can shift the
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