Stemming attacks on the pancreas In type 1 diabetes, autoreactive CD4 T cells attack and kill pancreatic β cells, disrupting insulin production. Many approaches have
Researchers have a new way to understand the much-studied Berlin patient’s unexpected cure from HIV and improve outcomes of stem cell transplants for patients with
Researchers have a new way to understand the much-studied Berlin patient’s unexpected cure from HIV and improve outcomes of stem cell transplants for patients with
Thanks to an international team of scientists and doctors, a seven-year-old Syrian refugee who lost most of his outer skin to a life-threatening genetic disease
A signature event for organoids Human cancer genomes harbor cryptic mutational signatures that represent the cumulative effects of DNA damage and defects in DNA repair
It emerges that high levels of vitamin C in blood-forming stem cells influence the number and function of the cells and affect the development of
Induced pluripotent stem cells (iPS cells) are a promising source for a cell-based therapy to treat Parkinson’s disease (PD), in which midbrain dopaminergic neurons progressively
By her 50th birthday, Els van der Heijden felt sicker than ever. Born with the hereditary disorder cystic fibrosis (CF), she had managed to work
Paul Knoepfler is an unlikely watchdog for the therapeutic stem cell industry. His University of California, Davis, lab mostly uses stem cells to study cancer-causing
Scientists in the U.S. have identified a molecular pathway that appears to play a key role in the link between a high-fat diet (HFD) and
Texas last week signaled its defiance of the federal government over unproven stem cell therapies, which are widely offered in the state for conditions including
In healthy individuals, chief cells, which are found at the base of corpus glands in the stomach, act as producers of digestive enzymes. However, if
Two teams of scientists have generated blood stem cells by reprogramming either human or mouse cells. In both cases, these hematopoietic stem cells successfully produced
Abstract Macrophages have diverse functions in immunity as well as development and homeostasis. Here we identify a function for these cells in long distance communication
Highlights •Stem cell lineage infidelity occurs transiently in wounds and persists in cancer •Wounds and cancer converge on lineage infidelity irrespective of stem cell origin
Islet transplantation is an established therapy for diabetes. We have previously shown that rat pancreata can be created from rat pluripotent stem cells (PSCs) in
Cardiac muscle cells derived from induced pluripotent stem cells (iPSCs) and injected into monkeys helped the animals’ hearts recover from a heart attack, according to
Donor stem cell–derived retinal epithelial cells whose immune proteins correspond to those of a recipient are tolerated following transplant into monkeys’ eyes, according to a
Zika virus exposure in a mouse model can infect adult neural stem cells in the brain, leading to cell death and reduced proliferation.CELL STEM CELL,
From mini brains to mini kidneys, an increasing number of organ models can now be grown in vitro. Some of these “organoids” can even perform
Chronic myeloid leukaemia (CML) arises after transformation of a haemopoietic stem cell (HSC) by the protein-tyrosine kinase BCR–ABL. Direct inhibition of BCR–ABL kinase has revolutionized
Pain can be tough to take, and it’s also difficult to study: rodent models for pain do not necessarily translate to human pain conditions and
A team of researchers at the Gladstone Institutes in San Francisco, California, has used a version of CRISPR gene editing known as CRISPR interference (CRISPRi) to
Retinitis pigmentosa, an inherited disease causing progressive degeneration of the retina, is repsonsible for blindness in approximately 1.5 million people worldwide. Using patient-derived stem cells,
Highlights •The aging Drosophila intestine is genetically mosaic •Somatic recombination, genomic deletions, and rearrangements occur in aging ISCs •Somatic inactivation of the tumor-suppressor Notch causes
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