Highlights Summary The ability to map trafficking for thousands of endogenous proteins at once in living cells would reveal biology currently invisible to both microscopy
Editor’s summary Cell layers can slip, slide, and fold in among one another during development to generate the complex forms of the biological world. Studying
Highlights Summary The pentameric FERRY Rab5 effector complex is a molecular link between mRNA and early endosomes in mRNA intracellular distribution. Here, we determine the
Highlights Summary Although the role of RNA binding proteins (RBPs) in extracellular RNA (exRNA) biology is well established, their exRNA cargo and distribution across biofluids are largely
Abstract Vision is initiated by the rhodopsin family of light-sensitive G protein-coupled receptors (GPCRs)1. A photon is absorbed by the 11-cis retinal chromophore of rhodopsin, which
Highlights • Structure of PCSK9/CHRD and an inhibitory nanobody that prevents LDLR degradation.• Binding of CAP1 to PCSK9 enhances its activity and abrogates nanobody inhibition.•
Abstract The early stages of the virus–cell interaction have long evaded observation by existing microscopy methods due to the rapid diffusion of virions in the
Making a mature cell skeleton Actin molecules are critical components of the cytoskeleton, controlling processes such as cellular organization, organelle trafficking, and force generation. Actin
Abstract Extracellular sulfatase-2 (Sulf-2) influences receptor–ligand binding and subsequent signaling by chemokines and growth factors, yet Sulf-2 remains unexplored in inflammatory cytokine signaling in the
Highlights •Plasma membrane ruffles are a mechanical immune signal caused by bacterial invasion •The mechanosensor PIEZO1 detects infection-induced ruffles and mediates Ca2+ influx •PIEZO1 activation triggers
Abstract Oocytes form before birth and remain viable for several decades before fertilization1. Although poor oocyte quality accounts for most female fertility problems, little is
Abstract Single pass cell surface receptors regulate cellular processes by transmitting ligand-encoded signals across the plasma membrane via changes to their extracellular and intracellular conformations.
Abstract Gasdermins (GSDMs) are a family of pore-forming effectors that permeabilize the cell membrane during the cell death program pyroptosis1. GSDMs are activated by proteolytic
Acne in action Adipogenesis plays a key role during deep tissue infection with Staphylococcus aureus, but the contribution of this process in acne caused by Cutibacterium acnes is
The making and removal of a leader When epithelia are injured, the remaining cells repair the epithelial sheet by migrating into and closing the open
Highlights •T. gondii bradyzoite and tachyzoite-infected cells show distinct transcriptional patterns •Protein export in bradyzoites is important for host transcriptional changes •The effector IST is exported in
Highlights •A neural network, STANN, models cell types in single-cell spatial transcriptomics data •Subsequent analyses reveal mouse brain architecture beyond conventional layers •Cellular colocalization and
Abstract Pro-inflammatory T cells in the central nervous system (CNS) are causally associated with multiple demyelinating and neurodegenerative diseases1,2,3,4,5,6, but the pathways that control these
Timing is said to be the secret to comedy and to success in life, but it could also be one of the secrets to a
Making ribosomes in human cells The assembly of the human ribosome requires a vast number of assembly factors that first form a giant precursor of
Highlights •Severe NaV1.2 deficiency results in enhanced neuronal excitability in adult mice •Increased excitability is accompanied by a higher voltage threshold in striatal MSNs •Hyperexcitability
Several RNA viruses can establish life-long persistent infection in mammalian hosts, but the fate of individual virus-infected cells remains undefined. Here we used Cre recombinase–encoding
More VEGF, more life span and health span Advanced aging is celebrated but its ill effects of deterioration at the cell, tissue, and organ levels
Highlights Intestinal prematurity is characterized by the lack of efficient IL-22 production rIL-22 enhances the regeneration and integrity of intestinal epithelium during NEC rIL-22-driven antimicrobial
Aging sees many physiological changes. Studies are revealing the dynamics of the cells and molecular factors that contribute to the aging process. For example, chronological
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