Birth of the Skin Microbiome
The skin is home to millions of commensal bacteria and immune cells. Yet how the skin microbiome is established in particular, why the immune system
The skin is home to millions of commensal bacteria and immune cells. Yet how the skin microbiome is established in particular, why the immune system
Jeanne Calment has nothing on Creme Puff, the cat. The oldest living human made it to the ripe age of 122 not bad for a
Obesogens, such as the extensively studied fungicide tributyltin (TBT), can act in a variety of ways to promote fat storage and adipose tissue production, often
Doctors wrote 259 million opioid prescriptions for Americans in 2012, enough to medicate every adult in the country. Drug overdoses are eclipsing car crashes as a leading cause of accidental death for
Oncogenic activation of BRAF fuels cancer growth by constitutively promoting RAS-independent mitogen-activated protein kinase (MAPK) pathway signalling1. Accordingly, RAF inhibitors have brought substantially improved personalized
Between October 2013 and July 2014, six healthy, middle-aged men reported to Temple University Hospital in north Philadelphia. For seven days, researchers confined each subject
A commonly prescribed antidepressant exerts epigenetic effects that may provide a useful biomarker of whether the drug works in patients. A team led by researchers
D2 dopamine receptors are targeted by antipsychotic agents to regulate behavior. Likhite et al. found putative arginine methylation motifs in some human G protein–coupled receptors
Cells read their environment to trigger an appropriate response for tissue homeostasis. Work now shows that intestinal progenitor cells use the RNA-binding protein Lin-28 to
We live in a world flooded with light 24 hours a day. Before our recent harnessing of electricity, light was a reliable indicator of seasonal
A process called the epithelial-to-mesenchymal transition allows cancer cells to invade nearby tissue and metastasize. Katz et al.investigated the molecular underpinnings of this process and
Exosomes are tiny vesicles released from cells that carry proteins, lipids, and nucleic acids: cargo that can affect the biology of recipient cells. In a
Researchers say that they have found a way to smuggle drug-carrying nanoparticles past the body’s immune system: by camouflaging them to look like cell fragments
Researchers say that they have found a way to smuggle drug-carrying nanoparticles past the body’s immune system: by camouflaging them to look like cell fragments
A protein embedded in the surface of mitochondria opens the door to apoptosis, causing cells to experience severe power failures, according to new work by
A possible approach for inducing cancer cells to revert to a precancerous state is based on the protein PLEKHA7 (Pleckstrin homology domain-containing family A member
Although recent studies have provided a wealth of information about archaeal biology, nothing is known about the molecular basis of DNA segregation in these organisms.
The types of lipids mice consume affect the composition of their gut microbiota, which influences whether the animals develop obesity-related inflammation, according to a study
Scientists at UC Davis have found that early exposure to inflammatory cytokines, such as interleukin 2, can stymie the activity of CD4 T cells, immune
The origins of new fat cells (adipocytes), which we humans must make throughout our lives, have not been clear. Rodent studies have produced conflicting results
The physiological differences between males and females go far beyond reproduction; they may even include how an animal processes pain, according to a study published
Identifying the molecular mechanisms that underlie aging and their pharmacological manipulation are key aims for improving lifelong human health. Here, we identify a critical role
The T790M mutation in EGFR accounts for approximately half of all lung cancer cases with acquired resistance to the current clinical EGFR tyrosine kinase inhibitors.
Different cell culture conditions can impact genetic changes in human embryonic stem cells (ESCs), and these changes could affect the cells’ clinical utility, according to
A multidisciplinary research team has discovered how cells know to rush to a wound and heal it opening the door to new treatments for diabetes,
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