Abstract Solid tumours are highly refractory to immune checkpoint blockade (ICB) therapies due to the functional impairment of effector T cells and their inefficient trafficking
Significance Although symptomatic medications are available, many temporal lobe epilepsy (TLE) patients remain unresponsive to treatment and new drug targets are needed. Connexin-based gap junctions
Multistage antimalarial Malaria is caused by infection with the protozoan parasite Plasmodium spp. and remains a serious global health threat. The emergence of resistance to existing antimalarial
Abstract New antibiotics should ideally exhibit activity against drug-resistant bacteria, delay the development of bacterial resistance to them and be suitable for local delivery at
Abstract Anti-cancer therapies often exhibit only short-term effects. Tumors typically develop drug resistance causing relapses that might be tackled with drug combinations. Identification of the
Abstract Genomic studies and experiments with permeability-deficient strains have revealed a variety of biological targets that can be engaged to kill Gram-negative bacteria. However, the
Abstract Trastuzumab deruxtecan is an antibody–drug conjugate with high extracranial activity in human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer. We conducted the
Designing around function Protein design has had success in finding sequences that fold into a desired conformation, but designing functional proteins remains challenging. Wang et al.
Macrophages modulate muscular dystrophy The role of resident macrophages in skeletal muscle regeneration after injury has previously been difficult to study. Here, Babaeijandaghi and colleagues
Abstract Acute myeloid leukemia (AML) is a heterogeneous group of aggressive hematological malignancies commonly associated with treatment resistance, high risk of relapse, and mitochondrial dysregulation.
Highlights •An unbiased genetic screen identifies effectors of AKT signaling as regulators of NMD •AKT phosphorylation of UPF1 overcomes autoinhibition of UPF1 helicase activity •AKT
Panning for antibiotics that stand out Despite their importance in modern medicine, antibiotics are under constant threat as pathogens adapt, acquire, or evolve resistance with
Abstract Immunosuppressive cells residing in the tumor microenvironment, especially tumor associated macrophages (TAMs), hinder the infiltration and activation of T cells, limiting the anti-cancer outcomes
Abstract Myeloid neoplasms are clonal hematopoietic stem cell disorders driven by the sequential acquisition of recurrent genetic lesions. Truncating mutations in the chromatin remodeler ASXL1
Abstract Biomacromolecules are highly promising therapeutic modalities to treat various diseases. However, they suffer from poor cellular membrane permeability, limiting their access to intracellular targets.
Abstract Background: Lower survival rates for many cancer types correlate with changes in nuclear size/scaling in a tumor-type/tissue-specific manner. Hypothesizing that such changes might confer
Abstract Preclinical studies of primary cancer cells are typically done after tumors are removed from patients or animals at ambient atmospheric oxygen (O2, ~21%). However,
New research has discovered that common artificial sweeteners can cause previously healthy gut bacteria to become diseased and invade the gut wall, potentially leading to
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is projected to be the second leading cause of cancer death in the USA by 2030. Immune checkpoint inhibitors fail
Abstract The emergence of drug-resistant bacteria calls for the discovery of new antibiotics. Yet, for decades, traditional discovery strategies have not yielded new classes of
A cheap, widely available drug used to treat mental illness cuts both the risk of death from COVID-19 and the need for people with the
Chronic pain that might be associated with nerve injury, or with metastatic cancer represents an unmet medical need. Researchers at Duke University Medical Center, and
Abstract Background Ototoxicity is a common adverse event of cisplatin treatment. The authors investigated the development of cisplatin-induced hearing loss (CIHL) over time in children
Abstract Bacteria in the gut can modulate the availability and efficacy of therapeutic drugs. However, the systematic mapping of the interactions between drugs and bacteria
Abstract Effective treatments of neurodegenerative diseases require drugs to be actively transported across the blood-brain barrier (BBB). However, nanoparticle drug carriers explored for this purpose
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