Neutrophils Lead, T Cells Follow
Part of the innate immune system, white blood cells called neutrophils circulate in the blood and are the first responders to an influenza respiratory infection,
Part of the innate immune system, white blood cells called neutrophils circulate in the blood and are the first responders to an influenza respiratory infection,
The candidate drug daratumumab, which is a monoclonal antibody that targets the cell surface molecule CD38 (cluster of differentiation 38), was shown to be a
n 1993, National Institutes of Health (NIH) researchers gave Eli Lilly’s promising experimental hepatitis B drug fialuridine to 15 patients as part of a small
A synthetic DNA–based vaccine targeting the Middle East respiratory syndrome coronavirus (MERS-CoV) protects rhesus macaques from developing symptoms of the disease. The vaccine also elicits
A magnetic blood filtering device is under development by start-up company MediSieve to capture and remove red blood cells infected with drug resistant malaria. The
The momentum of a cancer’s attack can be used against the cancer, say scientists who practice a form of molecular judo. Instead of directly blocking
Move over, poppies. In one of the most elaborate feats of synthetic bio logy to date, a research team has engineered yeast with a medley
At first glance, SPRITAM looks like any other pill. But the drug, developed by pharmaceutical company Aprecia, is actually layers of powder laid down by
A drug, tetrathiomolybdate (TM), which mops up copper in the body and that had already failed in a series of previous cancer clinical trials, is
After years of disappointment, clinical-trial results released on 22 July suggest that antibody treatments may produce small improvements in people with Alzheimer’s disease. The drugs
Researchers from Singapore‘s Nanyang Technological University (NTU), McLean Hospital, andHarvard Medical School report that they have found that existing anti- malaria drugs could be a
Broadly neutralizing antibodies, those that could squash a wide swath of virus types, are the supreme goal of HIV vaccine development. Although some people infected
Treatment directed at a newly identified drug target in rheumatoid arthritis (RA) would prevent damage to the joints while not increasing the immune suppression that
Building on previous work toward yeast–based opioid production, a team led by investigators at the University of California, Berkeley, has engineered a strain of yeast
The emergence of antibiotic-resistant bacteria is a growing public health concern and has serious implications for both human and veterinary medicine. The nature of the
Scientists at the University of Waterloo in Canada report that a new family of molecules that kill cancer cells while protecting healthy cells could be
A company that has spent more than 20 years trying to develop treatments based on embryonic stem cells is taking encouragement from small, preliminary tests
An experimental antibody drug aimed at protecting nerves from the ravages of multiple sclerosis offers hope for a new way to combat the neurological disease
Despite advances in analyzing tumor biology, choosing effective therapies for cancer patients remains difficult. This is partly because there are still no timely, foolproof ways
EDITOR’S CHOICE IN CELL & MOLECULAR BIOLOGY The paper C.A. Martz et al., “Systematic identification of signaling pathways with potential to confer anticancer drug resistance,”
Transcription factors form multiprotein complexes that coordinate gene expression and regulate cellular responses (1). In cancer, aberrantly expressed transcription factors often alter gene expression programs,
The US Food and Drug Administration (FDA) expanded the approved use of ibrutinib (Imbruvica) earlier today to include patients with Waldenström macroglobulinemia, a rare form
The stimulation of so-called brown fat the energy-burning kind is thought to be a potential therapeutic target for obesity. In a study published in Cell Metabolism
After years of debate, the US Food and Drug Administration (FDA) is poised to allow the sale of biosimilars, cheaper versions of complex and expensive
Many of the most widely used antibiotics have come out of the dirt. Penicillin came from Penicillium, a fungus found in soil, and vancomycin came
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