CRISPR tool modifies genes precisely by copying RNA into the genome
Variation in the DNA sequences that constitute the blueprint of life is essential to the fitness of any species, yet thousands of DNA alterations are
Variation in the DNA sequences that constitute the blueprint of life is essential to the fitness of any species, yet thousands of DNA alterations are
A clinical trial of a gene therapy for Duchenne muscular dystrophy has been halted after a patient suffered serious side effects following treatment, Reuters reports
Russian biologist Denis Rebrikov has started gene editing in eggs donated by women who can hear to learn how to allow some deaf couples to
Researchers have identified a genetic mutation that may help mitigate the risk of some forms of Alzheimer’s. In a study published yesterday (November 4) in
Preliminary research suggests that using CRISPR to treat cancer is safe in humans and could become a feasible therapeutic method in the future, although its
A new gene editing technique called prime editing, tested in human and mouse cells, rewrites DNA by only cutting a single strand to add, remove,
Definitive haematopoiesis in the fetal liver supports self-renewal and differentiation of haematopoietic stem cells and multipotent progenitors (HSC/MPPs) but remains poorly defined in humans. Here,
A study of nematode worms, mice, and humans indicates that, across the animal kingdom, with aging comes more neural activity and when this natural increase
Researchers have found a link between RNA splicing alterations and tau-mediated neurodegeneration in Alzheimer’s disease. The study, published today (October 8) in Cell Reports, examined
For the first time, scientists have found that complex sugars called glycans may bind to some RNA molecules, according to a bioRxiv preprint published September
To date, most cases of uniparental disomy—having two copies of a chromosome from either mom or dad, rather than one from each—have been identified in
A study published in Nature Medicine that found an increased mortality rate in people with an HIV-preventing gene variant has a major flaw, according to
Transcription and pre-mRNA splicing are key steps in the control of gene expression and mutations in genes regulating each of these processes are common in
Doctors, scientists, insurers, biotech companies. and patients themselves have long sought to be able to accurately predict (and extend) an individual’s longevity. And given the
In the early 2000s, Arturo Zychlinsky at the Max Planck Institute for Infection Biology in Berlin found that mammalian immune cells called neutrophils use an
A ew years ago, officials at Switzerland’s Federal Food Safety and Veterinary Office approached Hanno Würbel, the head of the animal welfare division at the
Molecules that combine elements of RNA and DNA, so-called chimeric molecules, may have been an important step in the emergence of life on Earth from
Development is often assumed to be hardwired in the genome, but several lines of evidence indicate that it is susceptible to environmental modulation with potential
Each human cell contains so much DNA — about 2 metres if extended — that it must be tightly wrapped around specialized histone proteins to
When I visited Ricaurte, Colombia, in 2016, I was surrounded by men with long faces and prominent ears. As we spoke, they would ask repetitive
Imagine a word processor that allowed you to change letters or words but balked when you tried to cut or rearrange whole paragraphs. Biologists have
his story introduces Science’s CRISPR in China series, supported by the Pulitzer Center. For many people, CRISPR plus China equals the biophysicist He Jiankui, who
Two well-known gene mutations work in tandem to allow endometrial cells, the cells that line the uterus, to migrate outside of the organ, a phenomenon
Genetics hold far more sway over the mouse microbiome than transient environmental exposures, researchers reported July 26 in Applied and Environmental Microbiology. The results appear
Searching a sample of DNA for a particular sequence—be it a mutation, a researcher-inserted transgene, or evidence of an infecting organism—is a common practice in
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