Isoform- and cell-state-specific lipidation of ApoE in astrocytes
Highlights •The N terminus of ApoE binds to PIPs and TAG in an isoform-specific manner •Lean astrocytes secrete cholesterol-loaded ApoE; this is unaffected by polymorphism
Highlights •The N terminus of ApoE binds to PIPs and TAG in an isoform-specific manner •Lean astrocytes secrete cholesterol-loaded ApoE; this is unaffected by polymorphism
Abstract HIV is difficult to eradicate due to the persistence of a long-lived reservoir of latently infected cells. Previous studies have shown that natural killer
T cells to fix a broken heart Making CAR T cells in vivo Abstract Acknowledgments Supplementary Materials References and Notes 0eLetters Making CAR T cells
Abstract Misfolding and aggregation of alpha-synuclein (αS) within dopaminergic neurons is a key factor in the development and progression of a group of age-related neurodegenerative
Significance Alongside αβ T cells and B cells, γδ T cells comprise a major component of the adaptive immune system, although a lack of bona
Highlights •MTHFD2 is critical for activated CD4 T cells to maintain de novo purine synthesis •Insufficient MTHFD2 promotes Treg cell-like phenotypes and metabolism in Th17 cells •Inhibition of
Abstract Glutathione (GSH) is a small-molecule thiol that is abundant in all eukaryotes and has key roles in oxidative metabolism1. Mitochondria, as the major site
Abstract A proteomics tool capable of identifying single proteins would be important for cell biology research and applications. Here, we demonstrate a nanopore-based single-molecule peptide
Highlights • Mitochondria in the mouse brain are long lived and show considerable age mosaicism• Mitochondria contain many LLPs as part of protein complexes• LLPs
Significance Dry age-related macular degeneration (AMD) affects the vision of millions of people worldwide. There is currently no Food and Drug Administration–approved treatment for dry
Highlights •We investigate the relationship of patient age and ICB therapy biomarkers •Favorable ICB biomarkers are generally more prevalent in elderly patients •The CAMA web
Abstract Methodologies for the controlled delivery of genetic information into target cells are of utmost importance for genetic engineering in both fundamental and applied research.
Infection with the SARS-CoV-2 virus can lead to diverse outcomes, ranging from no symptoms to varying degrees of disease severity, spanning mild illness to death.
SARS-CoV-2 is no Ferrari among viruses when it comes to mutations. Scientists reckon that its 30,000-base RNA genome acquires around two single-letter mutations a month, a rate
Astrocytes are glial cells that are abundant in the central nervous system (CNS) and that have important homeostatic and disease-promoting functions1. However, little is known
Abstract Introduction: Aging is characterized by the progressive loss of physiological capacity. At the cellular level, two key hallmarks of the aging process include telomere
Failure to smell fresh cut grass or a poo-laden diaper is, at least these days, a potential sign of COVID-19 infection. “People say things smell
Abstract Modern development of flexible electronics has made use of bioelectronic materials as artificial tissue in vivo. As hydrogels are more similar to nerve tissue, functional
When COVID-19 spread around the globe this year, David Montefiori wondered how the deadly virus behind the pandemic might be changing as it passed from
A study of COVID-19 patients at two London hospitals has identified blood-based immunological changes that are linked to the disease and, in some cases, to
As of today (January 23), 18 people have died from a newly identified coronavirus, and more than 630 have been infected. Airports are screening passengers
2019 Distribution of World’s First Malaria Vaccine Begins The World Health Organization and its partners will test the public health effect of immunization in parts
Discovery of a new T cell With all the extensive investigations scientists have conducted of the human immune system over the past century, it is
Stimulating or inhibiting particular neurons in an animal and observing the effects is the basis of countless neuroscience experiments. To achieve such control, researchers have
Koalas are susceptible to cancers such as lymphoma and leukemia along with chlamydia infections due to koala retrovirus, a pathogen that began inserting itself into
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