Scientists Look to Epigenetics to Thwart Viruses
When a virus invades a host cell, it needs to do some remodeling to make the environment safe for itself. In recent years, researchers have
When a virus invades a host cell, it needs to do some remodeling to make the environment safe for itself. In recent years, researchers have
In 2010, 5-year-old Emily Whitehead was diagnosed with acute lymphoblastic leukemia (ALL). Though her parents were told that if you had to have a kid
Today, August 30, 2017, the U.S. Food and Drug Administration approved a revolutionary, first-in-class cancer immunotherapy for children and young adults with relapsed or refractory
Abstract The apolipoprotein B messenger RNA-editing, enzyme-catalytic, polypeptide-like 3 (APOBEC3) family of cytidine deaminases plays an important role in the innate immune response to viral
Researchers have halted the progression of leukemia in mice by restoring the enzyme TET2 in hematopoietic stem cells, either by reestablishing its gene expression in
Only one case of locally transmitted Zika virus has been documented in the United States this year, a reflection of the fact that cases have
A minor proportion of people harbor a homozygous mutation in CCR5—a gene that encodes a receptor found on immune cells—that thwarts HIV’s attempts to get
T cells eliminate pathogens by recognizing foreign proteins that are expressed on the cell surface (antigens). T cell activation in response to antigen occurs for
Pregnant women and their children bear the destructive brunt of Zika, and since appreciating the connection between prenatal viral infection and the irreparable fetal harm
Although the Ebola outbreak in West Africa that started in 2013 was declared over more than a year ago, the disease lingers on. Many Ebola
Dupilumab is a fully human IgG4 monoclonal antibody directed against the IL-4Rα subunit of IL-4 and IL-13 receptors. It blocks the signaling pathways of IL-4
Metastasizing cancer cells travel through the lymphatic vasculature, but it’s not clear what role the formation of lymph vessels, called lymphangiogenesis, plays in cancer progression.
Inflammation in the gut, whether cartier bracelet caused by infection or autoimmunity, is challenging to detect, monitor, and treat. Riglar et al. engineered a strain
We describe the development of a nanoparticle platform that overcomes the immunosuppressive tumor microenvironment. These nanoparticles are coated with two different antibodies that simultaneously block
In 2015, gastroenterologist Edwin Liu set to work on a clinical and genetic data set that had been growing for more than 20 years. The
An immune checkpoint blocker successfully treated a variety of tumors in patients with gene mutations in a DNA fake cartier bracelets repair pathway, according to
The Ebola virus glycoprotein spike (white) bound by antibody fragments of the broadly neutralizing antibodies ADI-15878 (purple), ADI-15946 (blue), and ADI-16061 (green). Footprints of these
Detailed maps of the immune cells that surround tumours could suggest fresh therapeutic targets, point out biological markers that can be used to select the
Platelets do more than promote clotting. They weaken one of the body’s immune defenses against cancer. Unfortunately, platelets tend to work against the immuno-oncology treatments
Highlights •PD-L1 is primarily regulated by interferon gamma signaling in melanoma cells •PD-L2 is regulated by both interferon beta and gamma signaling •Regulation of PD-1
Resurrecting ancient proteins in modern E. coli can protect the bacterium from viral infection, scientists reported today (May 9) in Cell Reports. Researchers from Spain
When the immune system has eliminated the last traces of Zika virus from the blood, low-level infection may continue at certain sites around the body.
Highlights Pre-existing antibodies to DENV1 correlate with high ZIKV neutralizing responses Antibodies to the EDIII lateral ridge correlate with serum neutralization of ZIKV Recurrent VH3-23/VK1-5
A way to switch off IBD Inflammatory bowel diseases (IBDs) such as ulcerative colitis and Crohn’s disease are associated with defective interleukin-10 (IL-10) signaling. Although
Scientists at Dartmouth’s Norris Cotton Cancer Center have found that resident memory T cells can play an important role in preventing melanoma. The work began
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