Abstract Macrophages have a key role in shaping the tumour microenvironment (TME), tumour immunity and response to immunotherapy, which makes them an important target for
Highlights •During viral infection, inflammatory cytokines induce aerobic glycolysis in NK cells •Ldha expression is critical for clonal expansion of host-protective anti-viral NK and CD8+ T cells
Abstract SARS-CoV-2 proteins were measured in longitudinal plasma samples collected from 13 participants who received two doses of mRNA-1273 vaccine. 11 of 13 participants showed
Ebola virus (EBOV) glycoprotein (GP) can be recognized by neutralizing antibodies (NAbs) and is the main target for vaccine design. Here, we first investigate the
Highlights 16% of COVID-19 patients display an atypical low-inflammatory plasma proteome Severe COVID-19 is associated with heterogeneous plasma proteomic responses Death of virus-infected lung epithelial
Significance Current treatments for chronic inflammatory conditions rely on biologic drugs, commonly monoclonal antibodies that interfere with inflammatory signaling pathways. These drugs have made enormous
ABSTRACT SARS-CoV-2 is thought to have originated in the human population from a zoonotic spillover event. Infection in humans results in a variety of outcomes
Abstract This study examined whether CD8+ T-cell responses from COVID-19 convalescent individuals (n=30) potentially maintain recognition of the major SARS-CoV-2 variants (n=45 mutations assessed). Only
Abstract The spread of multidrug-resistance in Gram-negative bacterial pathogens presents a major clinical challenge, and new approaches are required to combat these organisms. Nitric oxide
Abstract TARM1 is a member of the leukocyte immunoglobulin-like receptor family and stimulates macrophages and neutrophils in vitro by associating with FcRγ. However, the function
A research team of pharmacists at the University of Bonn has discovered two families of active substances that can block the replication of the SARS-CoV-2
Highlights •Lung organoids express ACE2/TMPRSS2 and are permissive to SARS-CoV-2 infection •SARS-CoV-2 induces IFNs and cytokines/chemokines, and activates inflammasome pathway •SARS-CoV-2 infection in neurons activates
Significance Phosphohistidine (pHis) is a labile posttranslational modification with two isoforms, 1-pHis and 3-pHis, involved in many cellular processes across the kingdoms of life. Due
Infection with the SARS-CoV-2 virus can lead to diverse outcomes, ranging from no symptoms to varying degrees of disease severity, spanning mild illness to death.
Concerns about coronavirus variants that might be partially resistant to antibody defences have spurred renewed interest in other immune responses that protect against viruses. In
Good news from Israel. Researchers are seeing signs that COVID-19 vaccines are helping to curb infections and hospitalizations among older people, almost 6 weeks after
Abstract Phenotype-based compound screening has advantages over target-based drug discovery, but is unscalable and lacks understanding of mechanism of drug action. A chemical-induced gene expression
Ageing is characterized by the development of persistent pro-inflammatory responses that contribute to atherosclerosis, metabolic syndrome, cancer and frailty1–3. The ageing brain is also vulnerable
SARS-CoV-2 is no Ferrari among viruses when it comes to mutations. Scientists reckon that its 30,000-base RNA genome acquires around two single-letter mutations a month, a rate
Serum samples from 20 individuals who received the Pfizer-BioNTech vaccine against SARS-CoV-2 thwarted a version of the coronavirus with the so-called N501Y mutation, according to
Early action of IgA Humoral immune responses play a critical role in protecting individuals against SARS-CoV-2 infection, particularly through the activity of neutralizing antibodies. Sterlin et
As the number of people who have fought off SARS-CoV-2 climbs ever higher, a critical question has grown in importance: How long will their immunity
Resident help for fighting influenza Memory T cells take up residence in the lung after respiratory virus infection to facilitate rapid and localized immune responses
To reduce the occurrence of toxoplasmosis, scientists at the University of Zurich decided that they would pounce on oocyte production, the stage in the toxoplasmosis
Abstract Host-mediated lung inflammation is present,1 and drives mortality,2 in critical illness caused by Covid-19. Host genetic variants associated with critical illness may identify mechanistic targets for
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