Will Organs-in-a-Dish Ever Replace Animal Models?
From mini brains to mini kidneys, an increasing number of organ models can now be grown in vitro. Some of these “organoids” can even perform
From mini brains to mini kidneys, an increasing number of organ models can now be grown in vitro. Some of these “organoids” can even perform
Chronic myeloid leukaemia (CML) arises after transformation of a haemopoietic stem cell (HSC) by the protein-tyrosine kinase BCR–ABL. Direct inhibition of BCR–ABL kinase has revolutionized
Patients who receive blood stem cells from a donor run a risk of developing immediate life-threatening infections and, a month or so later, graft-versus-host disease
Pain can be tough to take, and it’s also difficult to study: rodent models for pain do not necessarily translate to human pain conditions and
A team of researchers from Israel and the U.S. has developed the first lines of human, haploid embryonic stems cells, according to a study published
Many tissues harbor a reservoir of stem cells that remains quiescent but can be activated as needed for growth and repair. How cells enter, maintain,
In numerous clinical trials, researchers have injected patients with various types of progenitor cells to help heal injured hearts. In some cases, subjects have ended
Retinitis pigmentosa, an inherited disease causing progressive degeneration of the retina, is repsonsible for blindness in approximately 1.5 million people worldwide. Using patient-derived stem cells,
Highlights •The aging Drosophila intestine is genetically mosaic •Somatic recombination, genomic deletions, and rearrangements occur in aging ISCs •Somatic inactivation of the tumor-suppressor Notch causes
Research into stem cells and aging aims to understand how stem cells maintain tissue health, what mechanisms ultimately lead to decline in stem cell function
Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), reprogrammed from adult differentiated cells, reportedly behaved differently from one another in myriad studies. But
Cells read their environment to trigger an appropriate response for tissue homeostasis. Work now shows that intestinal progenitor cells use the RNA-binding protein Lin-28 to
A revolutionary way of making stem cells claimed last year by Japanese and US researchers never existed in the first place. That is the conclusion
Chemotherapy-resistant cancer stem cells make it hard to cure many forms of the disease. Repositioning an existing drug to tackle this problem could significantly improve
Chinese stem-cell scientists have welcomed long-awaited measures that, state media claim, will rein in rogue use of stem cells in clinics while allowing research. The
Scientists have used two methods to generate patient-specific pluripotent stem cells with normal mitochondria for people with defects in these organelles, according to a study
Why primary tumors metastasize preferentially to particular organs is an important but still unanswered question in cancer biology. The tumor presumably communicates with the target
Researchers at the Salk Institute report the discovery of a new type of pluripotent stem cell whose identity is tied to its location in a
Scientists in Korea have injected human embryonic stem cell (hESC)-derived retinal support cells into the eyes of four men with macular degeneration, according to a
A company that has spent more than 20 years trying to develop treatments based on embryonic stem cells is taking encouragement from small, preliminary tests
Different cell culture conditions can impact genetic changes in human embryonic stem cells (ESCs), and these changes could affect the cells’ clinical utility, according to
A scientist at the University of Buffalo used an FDA-approved drug and human stem cells to increase the production of myelin in a myelin-deficient mouse
Scientists at the University of Manchester say they have used graphene to target and neutralize cancer stem cells while not harming other cells. This new development
Scientists at the University of Pittsburgh working with mice showed how stem cells harvested from teeth extracted during routine dental procedures can potentially be used
Pretreating human mesenchymal stem cells (MSCs) with a small molecule called Ro-31-8425, researchers can increase the expression of the surface receptor CD11a to improve the
Created by ePubSystems. Contact Us for similar site for your university or institute.