Personalized cancer treatments are no longer just options of the future. In the past few years, researchers have made significant progress in ‘teaching’ the body’s
Highlights •Measuring immunity to SARS-CoV-2 is key for understanding COVID19 and vaccine development •Epitope pools detect CD4+ and CD8+ T cells in 100 and 70% of convalescent
Immune warriors known as T cells help us fight some viruses, but their importance for battling SARS-CoV-2, the virus that causes COVID-19, has been unclear.
Our immune system’s killer T cells earn their name. They destroy infected and cancerous cells, and now, research reveals new details about how they do
Immune surveillance against pathogens and tumours in the central nervous system is thought to be limited owing to the lack of lymphatic drainage. However, the
Immune cells called CD8 (or cytotoxic) T cells can target and kill cancer cells, and immunotherapies that boost this process are in clinical use. However,
The immune system has evolved complex mechanisms that allow rapid and destructive responses to microbial intruders while sparing the host’s own tissues. Regulation of this
In a healthy adult, tissue-specific stem cells replenish damaged tissue and sustain plasticity (the addition of new cells) in organs. In two regions of the
Highlights • AMPK knockout in T cells accelerates acute lymphoblastic leukemia/lymphoma (T-ALL) • Oral treatment with phenformin delays T-ALL development in AMPK-dependent manner • Oral
Over the past 50 years, the frequency of allergies and autoimmune diseases has risen rapidly, but it’s not clear why. In a study published today
Scientists at UW Medicine’s Institute for Protein Design (IPD) in Seattle have created a new protein that mimics the action of a key immune regulatory
A hallmark of the disease multiple sclerosis is an inflammatory autoimmune attack1 on the proteins of the myelin sheath, a structure that wraps around the
The sleep disorder narcolepsy is linked to immune-system genes and is caused by the loss of neurons that express the protein hypocretin. Hypocretin-targeting immune cells
Ovarian cancer is a particularly hard-to-treat disease. It’s often diagnosed late, and even after surgery and chemotherapy, around 85 percent of patients relapse and develop
Abstract Genetically predisposed CTLA4 insufficiency in humans is associated with gastric cancer development, which is paradoxical to the prototypical role of CTLA4 in suppressing antitumor
Chemical groups tacked onto DNA or histone proteins regulate how and when genes are expressed. Environmental signals can change the placement of these epigenetic tags,
In this issue of JEM, Chheda et al. (https://doi.org/10.1084/jem.20171046) report that a conserved hotspot mutation associated with an aggressive form of brain cancer generates an
T cell non-Hodgkin lymphomas are a heterogeneous group of highly aggressive malignancies with poor clinical outcomes1. T cell lymphomas originate from peripheral T cells and
Researchers report promising results in a Phase 1 trial testing a new cell therapy using chimeric antigen receptor (CAR) T-cell technology on patients suffering from
Tumors can be divided into ‘hot’ (T cell inflamed) or ‘cold’ (T cell noninflamed) according to the presence of immune cells. In this review, we
Cancer researchers have shown how the activity of a specific protein enables regulatory T-cells (Tregs) to protect tumors from the immune system’s natural tracking and
An immune checkpoint blocker successfully treated a variety of tumors in patients with gene mutations in a DNA fake cartier bracelets repair pathway, according to
Detailed maps of the immune cells that surround tumours could suggest fresh therapeutic targets, point out biological markers that can be used to select the
Members of the interleukin-17 (IL-17) family of proinflammatory cytokines are important in the immune response to infections. However, too much IL-17 signaling is associated with
Antibodies that block CTLA-4 (cytotoxic T lymphocyte–associated antigen 4) and PD-1 (programmed death 1) allow T cells to launch antitumor immune responses. Although these checkpoint
Created by ePubSystems. Contact Us for similar site for your university or institute.