Abstract The analysis of cell-free DNA (cfDNA) in plasma provides information on pathological processes in the body. Blood cfDNA is in the form of nucleosomes,
Abstract Biomacromolecules are highly promising therapeutic modalities to treat various diseases. However, they suffer from poor cellular membrane permeability, limiting their access to intracellular targets.
Abstract RNAi therapy has undergone two stages of development, direct injection of synthetic siRNAs and delivery with artificial vehicles or conjugated ligands; both have not
Highlights •A reverse genetics approach determines genes required for normal cell division •Normal cell division requires genes of known and unknown function •JCVI-syn3A offers a
Researchers at EPFL have developed an approach to print tiny tissues that look and function almost like their full-sized counterpart. Measuring just a few centimeters
In a biological beating of swords into plowshares, researchers have converted a bacterial toxin into a genome editing tool that, for the first time, can
The Food and Drug Administration (FDA or Agency) plays a critical role in protecting the United States from public health threats including the Coronavirus Disease
Artificial intelligence tackles life science Look under the hood of many of this year’s headline-making discoveries in biology and you’ll find machine learning, a tool
Since 2006, when Shinya Yamanaka, now the director of the Center for iPS Cell Research and Application at Kyoto University, discovered a method that could
The mammalian brain consists of billions of neurons wired together in various circuits, each one involved in specific physiological functions. To better understand how these
A new gene editing technique called prime editing, tested in human and mouse cells, rewrites DNA by only cutting a single strand to add, remove,
Doctors, scientists, insurers, biotech companies. and patients themselves have long sought to be able to accurately predict (and extend) an individual’s longevity. And given the
A ew years ago, officials at Switzerland’s Federal Food Safety and Veterinary Office approached Hanno Würbel, the head of the animal welfare division at the
One day, doctors may be able to use the metabolites in blood samples to predict the likelihood of a person surviving another five to 10
A mesh-like network of cells within mice’s skin plays a previously unknown role in pain perception, researchers reported today (August 16) in Science. The scientists
What you see in the image above is a lobe of a liver, times two—on the right, a flesh-and-blood one, removed from a transplant donor,
Using human embryonic stem cells (ES cells), researchers have generated models of early human embryos in the lab that are more complex than any previous
Researchers have developed lab-generated lymph node–like organoids that, when transplanted into mice in place of lymph nodes that have been removed, drain fluid and connect
In mice whose sense of smell has been disabled, a squirt of stem cells into the nose can restore olfaction, researchers report today (May 30)
Vaccines prevent millions of deaths a year and have pushed some diseases to the edge of existence. Yet it’s proven highly challenging, if not impossible,
In the murky darkness, blue and green blobs are dancing. Sometimes they keep decorous distances from each other, but other times they go cheek to
For a small fold of tissue, the hippocampus has an outsized influence. It stores and retrieves human memories, capturing the life history that makes us
Current genetic testing methods often fall short in diagnosing pediatric patients with developmental delay, intellectual disability, or congenital abnormalities. Sometimes, this is because certain genetic
Researchers have come up with a new method to control brain cells in live animals using specially designed receptor proteins that respond to the drug
Genetically engineered yeast produce the cannabinoids THC and CBD, researchers reported today (February 27) in Nature. Much like in their typical application of brewing beer,
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