Genetic requirements for cell division in a genomically minimal cell
Highlights •A reverse genetics approach determines genes required for normal cell division •Normal cell division requires genes of known and unknown function •JCVI-syn3A offers a
Highlights •A reverse genetics approach determines genes required for normal cell division •Normal cell division requires genes of known and unknown function •JCVI-syn3A offers a
Enhancing EGFR to offset osteoarthritis Cartilage degeneration in osteoarthritis causes pain and limits mobility. Wei et al. investigated epidermal growth factor receptor (EGFR) signaling as a potential
Abstract Chaperones are essential for assisting protein folding and for transferring poorly soluble proteins to their functional locations within cells. Hydrophobic interactions drive promiscuous chaperone-client
Abstract Cells rely upon producing enzymes at precise rates and stoichiometry for maximizing functionalities. The reasons for this optimal control are unknown, primarily because of
Highlights •NSP16 binds mRNA recognition domains of U1/U2 snRNAs and disrupts mRNA splicing •NSP1 binds in the mRNA entry channel of the ribosome to disrupt
Highlights •Systematic analysis reveals G protein selectivity of all canonical RGS proteins •RGS proteins rely on selectivity bar codes for selective G protein recognition •Transplantation
ABSTRACT An outbreak of the novel coronavirus SARS-CoV-2, the causative agent of COVID-19 respiratory disease, has infected over 290,000 people since the end of 2019,
Abstract Caspase-dependent apoptosis accounts for approximately 90% of homeostatic cell turnover in the body1, and regulates inflammation, cell proliferation, and tissue regeneration2,3,4. How apoptotic cells
Multicellular life requires individual cells to cooperate in a way that benefits the organism. Cells that are uncooperative because they are damaged or dysfunctional, and
In one of the University of Sheffield’s physics labs, a few hundred photosynthetic bacteria were nestled between two mirrors positioned less than a micrometer apart.
Exposure of cells to acidic conditions outside the cell activates chloride-conducting channels that influence physiological and pathological processes. Yang et al. used an unbiased RNA
HeLa cells have now been cultured for nearly 70 years in many labs across the world, and were long considered to be an infinite supply
An international team of researchers has successfully reprogrammed human α cells into insulin-producing β cells, according to a study published yesterday (February 13) in Nature.
In 2007, Ho Man “Holly” Tang took a break from her undergraduate biology studies at Iowa State University to join her older brother, Ho Lam
Highlights • Single-cell RNA-seq stratifies patients with similar clinical presentation • A pseudotemporal profile aligns single cells along a control to disease axis • HDAC4
A major cause of type 2 diabetes is obesity, in which fat cells expand rapidly, in both size and number, and their oxygen demand outstrips
Cellular metabolism is an interconnected network of chemical reactions, each step catalyzed by dedicated enzymes. Inhibition or intentional removal of an enzyme should grind the
CD95/Fas ligand binds to the death receptor CD95 to induce apoptosis in sensitive cells. We previously reported that CD95L mRNA is enriched in sequences that,
Setting liver regeneration free The liver is an excellent model of organ regeneration; however, regeneration may fail in a normal liver after acute severe injury
Cytokines and interferons initiate intracellular signaling via receptor dimerization and activation of Janus kinases (JAKs). How JAKs structurally respond to changes in receptor conformation induced
Highlights •SRPKIN-1 is the first irreversible inhibitor for SRPK1/2 kinase •SRPKIN-1 is the first kinase inhibitor that targets a tyrosine residue covalently •SRPKIN-1 inhibits phosphorylation
When cells migrate, they normally do so by adopting a characteristic polarized morphology with the nucleus seemingly pushing from behind. The internal cytoskeleton forms well-organized
Highlights •In contrast to animals, how bacteria behave during combat is poorly understood •Escherichia coli use diverse strategies when attacking opponents with colicin toxins •Cells
A new paper claims that there may be no such thing as a maximum life span for naked mole rats. As these burrowing, sausage-shaped rodents
Abstract The recent advent of methods for high-throughput single-cell molecular profiling has catalyzed a growing sense in the scientific community that the time is ripe
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