Sourcing Painkillers from Scorpions’ Stings
Studying scorpions comes with its share of danger, as biologist Bryan Fry of the University of Queensland knows all too well. On a 2009 trip
Studying scorpions comes with its share of danger, as biologist Bryan Fry of the University of Queensland knows all too well. On a 2009 trip
Highlights •GPCRs targeted by FDA-approved drugs show genetic variation in the human population •Genetic variation occurs in functional sites and may result in altered drug
Report of a novel class of highly potent and selective rhomboid inhibitors. Rhomboids are implicated in several devastating human afflictions including malaria, diabetes, cancer, and
Tuberculosis is no longer on the LAM Lipoarabinomannan (LAM) is a component of the cell wall shed by Mycobacterium tuberculosis, the bacteria responsible for tuberculosis,
In recent years, a number of investigations revealed that clinical reporting practices failed to meet ethical and legal standards in both academia and industry. But
Summary Nearly all of the roughly 64,000 Americans who died from opioid overdoses in 2016 succumbed because their breathing shut down, triggered by the effects
On a fall day in 2015 at Sunnybrook hospital in Toronto, a dozen people huddled in a small room peering at a computer screen. They
Even where drugs did show survival gains over existing treatments, these were often marginal, the results show. Many of the drugs were approved on the
Abstract Sulfonylureas are anti-diabetic medications that act by inhibiting pancreatic KATP channels composed of SUR1 and Kir6.2. The mechanism by which these drugs interact with
Numerous microorganisms, including bacteria, colonize the intestine where they play important roles in maintaining homeostasis. However, commensal bacteria with pathogenic potential, such as Helicobacter hepaticus,
A team of molecular microbiologists used quantum dot technology to increase the efficacy of antibiotics to the point where they became capable of killing strains
A powerful new way of analysing how drugs interact with molecules in the body could aid the design of better treatments with fewer side-effects. Most
Cancer researchers have are warning drug developers that in about 62% of ovarian cancer cell samples levels of messenger RNA and protein did not accurately
Takinib, a selective TAK1 inhibiting drug, has been shown to broaden the therapeutic efficacy of TNF-alpha (Tumor necrosis factor-alpha) inhibition for treating cancer and autoimmune
Gut microbes possibly influence not only the development of many human diseases, but also how these diseases respond to treatment. In tumor models, for example,
Abstract Streptococcus mutans employs a key virulence factor, three glucosyltransferase (GtfBCD) enzymes to establish cariogenic biofilms. Therefore, the inhibition of GtfBCD would provide anti-virulence therapeutics.
A popular chemogenetic technique for controlling cells does not operate in vivo in the way scientists had assumed. Reporting in Science yesterday (August 3), researchers
Summary Rucaparib is an inhibitor of nuclear poly (ADP-ribose) polymerases (inhibition of PARP-1 > PARP-2 > PARP-3), following a similar drug, Olaparib. It disrupts DNA
A new treatment strategy has had astonishing success against extensively drug-resistant tuberculosis (XDR TB), which kills more than 70% of patients. XDR and other drug-resistant
Evidence suggests that, in people with previous colorectal neoplasia, aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs) lower risk for metachronous neoplasia (i.e., occurring after resection of
Engineering cells to regulate glucose Diabetes mellitus affects hundreds of millions of people worldwide. Blood glucose levels are chronically deregulated in diabetics, and this can
BACKGROUND The escalating crisis of multidrug resistance is raising fears of untreatable infections caused by bacterial “superbugs.” However, many patients already suffer from infections that
Modern agriculture relies on antibiotics to shield livestock from disease, but widespread over-use of antibiotics has raised concerns over creating highly resistant “superbugs.” Researchers announced
On 26 January, Ling Wang and Qinzi Xu, two biomedical scientists at the University of Pittsburgh in Pennsylvania, placed a mouse under a chemical hood,
At present, there are no disease-modifying treatments to stall the progression of Parkinson’s disease (PD). A drug in development to treat diabetes might provide a
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