Scientists use a “big data” approach to precision medicine
In a new study, researchers compared genetic mutations in patient tumours to those in cancer cell lines and then tested the cell lines’ responses to
In a new study, researchers compared genetic mutations in patient tumours to those in cancer cell lines and then tested the cell lines’ responses to
Following the deaths of three patients in a phase II cancer immunotherapy clinical trial, Juno Therapeutics has put the brakes on the study. The firm
Researchers have identified a gene that kickstarts the male-specific genetic program in the African malaria mosquito Anopheles gambiae. When expressed in genetically female mosquito embryos,
Natural products have historically been of crucial importance in the identification and development of antibacterial agents. Interest in these systems has waned in recent years,
Hemophilia A is a bleeding disorder caused by a deficiency of factor VIII, a protein essential for blood clotting. Injection of recombinant or plasma-derived factor
A team of Swiss drug developers has designed a novel drug that cures breast cancer by completely blocking the activity of the surface receptor HER2
Multiple sclerosis (MS) is an autoimmune disorder characterized by T cell-mediated demyelination and neurodegeneration in the CNS (Friese and Fugger, 2005, Pender and Greer, 2007, Sospedra
Researchers at the US National Cancer Institute (NCI) have successfully visualized the structures of enzymes at near-atomic resolutions previously not considered possible, using cryo-electron microscopy
Evolutionary biologists have begun studying the rise of antibiotic resistance, one of the most urgent problems in public health. Their work suggests that old dogmas
n July 2011, a 43-year-old woman walked out of the National Institutes of Health (NIH) Clinical Center in Bethesda, Maryland, after a month of battling
Diabetics who use the commonly prescribed drug metformin to control blood sugar levels have a different composition of gut microbiota than other diabetics, according to
Doctors wrote 259 million opioid prescriptions for Americans in 2012, enough to medicate every adult in the country. Drug overdoses are eclipsing car crashes as a leading cause of accidental death for
Several years ago, antiobesity drug development was not looking so hot. In 2007, Sanofi-Aventis failed to win US Food and Drug Administration (FDA) approval for
A commonly prescribed antidepressant exerts epigenetic effects that may provide a useful biomarker of whether the drug works in patients. A team led by researchers
A toxic anticancer therapeutic agent was encapsulated in capsules derived from apoferritin, which sequestered the drug until its selective delivery to cancer cells. Ferritin is
After downsizing its chimp research program over the past several years, the National Institutes of Health (NIH) will send its remaining animals to sanctuaries. “It
Sanofi will use technology licensed from Hanmi Pharmaceutical to develop a portfolio of long-acting diabetes treatments. The licensing agreement, announced today, indicates that the technology,
Researchers in Australia added an adjuvant to an inactivated influenza A vaccine and successfully boosted the shot’s effectiveness and cross-protective capabilities, according to a study
Chronic myelogenous leukemia (CML) is caused by chromosomal translocation that creates a fused gene; this gene produces an oncoprotein, BCR-ABL. Targeting this protein with imatinib
Mouse models do not fully capture the degeneration of brain networks seen in human Alzheimer’s disease (AD). Thus, extensive validation of therapeutic targets in many
Mouse models do not fully capture the degeneration of brain networks seen in human Alzheimer’s disease (AD). Thus, extensive validation of therapeutic targets in many
Brown fat the form of adipose tissue that burns, rather than stores, energy was only recently discovered to exist in adult humans. For decades, researchers
Methicillin-resistant Staphylococcus aureus (MRSA) is a worldwide threat to human health, because it is resistant to a large class of β-lactams (penicillins) and to second-generation
Researchers at the pharmaceutical company Merck have identified a new bacteria-killing compound with an unusual target—an RNA regulatory structure called a riboswitch. The team used
Since the year 2000, a concerted campaign against malaria has led to unprecedented levels of intervention coverage across sub-Saharan Africa. Understanding the effect of this
Created by ePubSystems. Contact Us for similar site for your university or institute.