Zika virus — concerns for male fertility
Although Zika virus (ZIKV) has been detected in the semen of men months after initial infection, the consequences of retention of the virus in the
Although Zika virus (ZIKV) has been detected in the semen of men months after initial infection, the consequences of retention of the virus in the
S ince the dawn of microbiology, researchers have focused on pathogens that make us and our domesticated animals and plants sick. Because the onset of
The first reports of the disease that would later be known as HIV/AIDS came in 1981, when AIDS-related conditions were already on the rise, particularly
Most viral infections trigger B cells to produce neutralizing antibodies, but for a handful of viruses that cause chronic infections, B cells are for some
A preventive DNA vaccine encoding two Zika structural proteins protected Rhesus macaques from viral infection. The results, published today (September 22) in Science, are encouraging
Scientists from Fred Hutchinson Cancer Research reported data from an early-phase study of patients with advanced non-Hodgkin’s lymphoma (NHL) who received JCAR014, a chimeric antigen
Amyloid-β proteins form plaques in the brain that are a hallmark of Alzheimer’s disease. Designed to clear these plaques, the antibody aducanumab is demonstrating early
Each newly-formed T cell bears a unique T cell receptor (TCR) that recognizes a particular antigen. But how a given TCR shapes the fate of
In mice, severely restricting caloric intake promotes the transformation of white fat into brown fat, which contains cells that burn energy faster, according to a
Scientists studying Zika are moving quickly to generate a vaccine against the mosquito-borne virus that continues to spread through South and Central America and is
Cyclin suppresses antitumor immunity Despite the dramatic success of cancer immunotherapy, many types of cancer do not respond. Understanding why could help us to find
Following the deaths of three patients in a phase II cancer immunotherapy clinical trial, Juno Therapeutics has put the brakes on the study. The firm
The malaria vaccine doesn’t provide lasting protection against the mosquito-borne disease, according to a study published yesterday (June 29) in NEJM: it delays infections by
Multiple sclerosis (MS) is an autoimmune disorder characterized by T cell-mediated demyelination and neurodegeneration in the CNS (Friese and Fugger, 2005, Pender and Greer, 2007, Sospedra
Plaques of amyloid-β peptides in certain parts of the brain are a telltale sign of Alzheimer’s disease–associated neurodegeneration. When not in pathological aggregates, these peptides—found
Patients who receive blood stem cells from a donor run a risk of developing immediate life-threatening infections and, a month or so later, graft-versus-host disease
Regular exercise reduces the risk of cancer and disease recurrence. Yet the mechanisms behind this protection remain to be elucidated. In this study, tumor-bearing mice
An antibody to block viral fusion A small fraction of HIV-1–infected individuals develop broad and potent antibodies that bind the HIV-1 envelope protein (Env). These
Zika virus has frightened people the world over because of growing evidence that it can have severe effects on fetuses when it infects pregnant women.
Two companies in Brazil are taking a creative approach to controlling populations of Zika-carrying mosquitoes: creating billboards that mimic the smell of human breath and
As we age, our immune systems change; in many ways not for the better. For instance, the elderly account for 90% of influenza deaths annually.
The ongoing Zika virus epidemic is of grave concern because of its apparent links to congenital microcephaly and Guillain-Barré syndrome. Sirohi et al. present a
Cancer research is a rapidly evolving field with new discoveries emerging daily on its biology, prevention, diagnosis, and treatment. In particular, the recent achievement of several
CRISPR/Cas9 gene editing has shown remarkable therapeutic potential, including the ability to fightpathogens like HIV. But the same process that inactivates the deadly virus may
As concerns over the spread of Zika virus through the Americas rise, and evidence showing that the virus can infect developing neurons accumulates, a team led
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