Accumulating evidence indicates that dysregulation of microbiota-host interactions associates with various diseases, including inflammatory bowel diseases (IBDs), colorectal cancer, diabetes, and liver cirrhosis (1). Recently,
Aminoglycoside antibiotics bind to bacterial ribosomes and inhibit protein synthesis. Eukaryotic ribosomes, in contrast, are not strongly inhibited by these molecules but show errors such
When cells in our body die, it is important that they are cleared from the system so that they do not cause inflammation or further
G-protein-coupled receptors mediate the biological effects of many hormones and neurotransmitters and are important pharmacological targets1. They transmit their signals to the cell interior by
Highlights •Different EGFR ligands stabilize receptor dimers with distinct structures •Epiregulin and epigen induce weaker and more short-lived EGFR dimers than EGF •Weakened dimerization causes
The p53 transcription factor is a critical barrier to pancreatic cancer progression. To unravel mechanisms of p53-mediated tumor suppression, which have remained elusive, we analyzed
Abstract Transient increases in mitochondrially-derived reactive oxygen species (ROS) activate an adaptive stress response to promote longevity. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases produce ROS
NA comes in many shapes and sizes. Over the past few decades, researchers have characterized at least two dozen different RNA varieties beyond the textbook
In this issue of JEM, Marciniak et al. (https://doi.org/10.1084/jem.20161731) identify a putative novel function of tau protein as a regulator of insulin signaling in the
Abstract Activating mutations cartier love bracelet involving hermes belt the PI3K pathway occur frequently in human cancers. However, PI3K inhibitors primarily induce cell cycle arrest,
Around half of all organ transplants in humans are rejected by the cartier jewelry replica recipient’s immune system within 10 to 12 years. Scientists studying
G-protein-coupled receptor (GPCR)-mediated signal transduction is central to human physiology and disease intervention, yet the molecular mechanisms responsible for ligand-dependent signalling responses remain poorly understood.
Targeting upstream phosphatidylinositol-3-kinases (PI3Ks) in the PI3K/Akt/mTOR pathway appears to be a promising therapy in solid cancers; however, first early clinical trials with PI3K inhibitors
As many as 8 percent of pregnant women develop a condition known as preeclampsia, a spike in blood pressure characterized by the reduced formation of
Abstract Macrophages have diverse functions in immunity as well as development and homeostasis. Here we identify a function for these cells in long distance communication
Adenosine triphosphate (ATP) is the canonical energy carrier that powers cellular machines, drives metabolic reactions, and serves as a precursor to nucleic acids. On page
Type I diabetes had rendered a 43-year-old woman dependent on insulin, until doctors restored her body’s ability to produce the hormone with engineered islet cells
Detailed maps of the immune cells that surround tumours could suggest fresh therapeutic targets, point out biological markers that can be used to select the
Highlights •PD-L1 is primarily regulated by interferon gamma signaling in melanoma cells •PD-L2 is regulated by both interferon beta and gamma signaling •Regulation of PD-1
Some pathogens block generation of reactive oxygen species to evade neutrophil killing, but how that is accomplished is poorly understood. In this issue of Cell
During senescence, cells remain in a state of growth arrest. Accumulation of similar nonfunctional cells has been linked to chronic inflammatory diseases and degenerative disorders.
Give us our daily protein Protein is an essential component of our food, and protein intake thus must be actively regulated. Liu et al. identified
Highlights GRK5-β2AR binding is enhanced by receptor and kinase ligands and acidic lipids GRK5 binding to the β2AR involves a multi-site interaction Receptor binding triggers
In this issue of Cell, Baar et al. show how FOXO4 protects senescent cell viability by keeping p53 sequestered in nuclear bodies, preventing it from inducing
During infection, malaria parasites must invade erythrocytes. Erythrocytes are flexible cells that can easily deform to make it through the tight spaces of the vasculature,
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