Engineering an immune cell to recognize and kill a cancer cell is the key to chimeric antigen receptor (CAR) T-cell therapy, but modified immune cells
Exciting progress in the field of cancer immunotherapy has renewed the urgency of the need for basic studies of immunoregulation in both adaptive cell lineages
Researchers have a new way to understand the much-studied Berlin patient’s unexpected cure from HIV and improve outcomes of stem cell transplants for patients with
Researchers have a new way to understand the much-studied Berlin patient’s unexpected cure from HIV and improve outcomes of stem cell transplants for patients with
Tumors can be divided into ‘hot’ (T cell inflamed) or ‘cold’ (T cell noninflamed) according to the presence of immune cells. In this review, we
Some malaria researchers say their worst fears are coming true. A malaria parasite resistant to resistant to a first-line artemisinin combination therapy has rapidly made
In 2010, 5-year-old Emily Whitehead was diagnosed with acute lymphoblastic leukemia (ALL). Though her parents were told that if you had to have a kid
Today, August 30, 2017, the U.S. Food and Drug Administration approved a revolutionary, first-in-class cancer immunotherapy for children and young adults with relapsed or refractory
Only one case of locally transmitted Zika virus has been documented in the United States this year, a reflection of the fact that cases have
In this issue of Cancer Cell, Saha et al. systematically test and optimize combination therapy strategies in a challenging model of glioblastoma. Durable complete responses
Detailed maps of the immune cells that surround tumours could suggest fresh therapeutic targets, point out biological markers that can be used to select the
Highlights Pre-existing antibodies to DENV1 correlate with high ZIKV neutralizing responses Antibodies to the EDIII lateral ridge correlate with serum neutralization of ZIKV Recurrent VH3-23/VK1-5
A way to switch off IBD Inflammatory bowel diseases (IBDs) such as ulcerative colitis and Crohn’s disease are associated with defective interleukin-10 (IL-10) signaling. Although
Emerging evidence indicates that the immune system can influence microbiome composition. Chen et al. now report that patients with active ulcerative colitis have low expression
The outlook for patients with multiple myeloma has improved dramatically during the past two decades. The median overall survival is now more than 6 years,
In 2015, 17 million HIV-infected individuals worldwide were on antiretroviral drug therapies, which are remarkably effective in suppressing the virus. Yet, 6000 people a day
Zika is a mosquito-borne, sexually transmissible virus that is now known to cause a variety of birth defects. The ongoing epidemic of Zika virus infection
Neutrophil extracellular traps (NETs), made of processed chromatin bound to cytotoxic enzymes, are released by neutrophils into the extracellular space to control microbial infections. However,
S ince the dawn of microbiology, researchers have focused on pathogens that make us and our domesticated animals and plants sick. Because the onset of
Tumor cells undergoing metastasis prompt neutrophils to extrude stringy DNA webs known as neutrophil extracellular traps (NETs) that help the cancer invade other tissues, according
Most viral infections trigger B cells to produce neutralizing antibodies, but for a handful of viruses that cause chronic infections, B cells are for some
Scientists from Fred Hutchinson Cancer Research reported data from an early-phase study of patients with advanced non-Hodgkin’s lymphoma (NHL) who received JCAR014, a chimeric antigen
Each newly-formed T cell bears a unique T cell receptor (TCR) that recognizes a particular antigen. But how a given TCR shapes the fate of
Single-agent immunotherapy has achieved limited clinical benefit to date in patients with pancreatic ductal adenocarcinoma (PDAC). This may be a result of the presence of
Patients who receive blood stem cells from a donor run a risk of developing immediate life-threatening infections and, a month or so later, graft-versus-host disease
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